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ZIRC
ZFIN ID: ZDB-GENE-041001-150
Gene Name: churchill domain containing 1
Gene Symbol: churc1    Nomenclature History

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Previous Names: chch (1), si:dkey-12h9.10, zgc:101863

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have zinc ion binding activity. Involved in several processes, including cell migration involved in gastrulation; fibroblast growth factor receptor signaling pathway involved in somitogenesis; and negative regulation of fibroblast growth factor receptor signaling pathway. Is expressed in several structures, including digestive system; ethmoid cartilage; forerunner cell group; keratinocyte; and mucus secreting cell. Orthologous to human CHURC1 (churchill domain containing 1).
Genome Resources: Alliance (1),  Gene:492508 (1),  Ensembl(GRCz11):ENSDARG00000010831 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101863]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5951 Point Mutation Unknown Premature Stop ENU
sbu48 Insertion Unknown Frameshift ZINC_FINGER_NUCLEASE
sbu49 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
sbu50 Indel Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-churc1
2
MO1-churc1 N/A 2
MO2-churc1 N/A 1
DISEASE ASSOCIATED WITH churc1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH churc1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell migration involved in gastrulation (more)
Molecular Function metal ion binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009508 (1)
  • InterPro:IPR036280 (1)
  • InterPro:IPR038543 (1)
  • Pfam:PF06573 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA churc1-201 (1)    Ensembl 901
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM churc1 No data available
    MARKER RELATIONSHIPS
    churc1 Contained in: [BAC] DKEY-12H9 (1) (order this)
    churc1 Encodes: [cDNA] MGC:101863 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007380 (1) 923 bp
    Genomic GenBank:AL954831 (1) 230844 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QKJ4 (1) 118 aa
    Sequence Clusters UniGene:79574 (1)
    Sequence Information (all 15)
    ORTHOLOGY for churc1 ( Chr: 20 )
    CITATIONS (24)