Gene

mthfd1l

ID
ZDB-GENE-041001-133
Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
Symbol
mthfd1l Nomenclature History
Previous Names
  • fk48e08
  • si:dkey-25e12.5
  • si:dkey-25e12.6
  • wu:fk48e08
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to localize to cytosol. Is expressed in anterior neural tube and optic cup. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Lee et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mthfd1l Human Ortholog
No data available
Associated With mthfd1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020628 Formate-tetrahydrofolate ligase, FTHFS, conserved site
Domain IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family IPR000559 Formate-tetrahydrofolate ligase, FTHFS
Family IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Formate-tetrahydrofolate ligase, FTHFS Formate-tetrahydrofolate ligase, FTHFS, conserved site NAD(P)-binding domain superfamily P-loop containing nucleoside triphosphate hydrolase Tetrahydrofolate dehydrogenase/cyclohydrolase Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
UniProtKB:A0A2R8RW82 978
UniProtKB:Q5PNN5 263
UniProtKB:Q5PNN3 122
UniProtKB:F1QQ79 978
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations