ZFIN ID: ZDB-GENE-041001-112
Gene Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Gene Symbol: kdr    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, vegfr2b (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have vascular endothelial growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in angiogenesis. Predicted to localize to the endoplasmic reticulum; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Orthologous to human KDR (kinase insert domain receptor).
Genome Resources: Alliance (1),  Gene:554230 (1),  Ensembl(GRCz11):ENSDARG00000017321 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn0383Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13239 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23684 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43425 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43426 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uq38bh Insertion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdr 1
    MO1-kdr N/A 11
    MO2-kdr N/A 3
    MO3-kdr N/A 2
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH kdr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hemangioma, capillary infantile, somatic 602089
    {Hemangioma, capillary infantile, susceptibility to} 602089
    DISEASE ASSOCIATED WITH kdr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function protein binding (more)
    GO Terms (all 37)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Family IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041348 VEGFR-2, Transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdr-201 (1)    Ensembl 5381
    ottdart00000005209 (1) 1393
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM kdr
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg1(kdr:EGFP) kdr EGFP Danio rerio 1 4
    Tg2(kdr:EGFP) kdr EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    kdr Contained in: [BAC] CH211-254J6, CH211-278F21 (1)
    [PAC] BUSM1-205D10
    kdr Encodes: [cDNA] MGC:195121 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001024653 (1) 5360 bp
    Genomic GenBank:BX088688 (1) 179801 bp
    Select Tool
    Polypeptide UniProtKB:Q5GIT4 (1) 1357 aa
    Sequence Information (all 21)
    ORTHOLOGY for kdr ( Chr: 20 )
    CITATIONS (101)