Gene

kdr

ID
ZDB-GENE-041001-112
Name
kinase insert domain receptor (a type III receptor tyrosine kinase)
Symbol
kdr Nomenclature History
Previous Names
  • kdrb
  • si:busm1-205d10.1
  • si:ch211-254j6.1
  • si:ch211-278f21.4
  • vegfr2b (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in angiogenesis. Predicted to localize to endoplasmic reticulum; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Orthologous to human KDR (kinase insert domain receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kdr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hemangioma, capillary infantile, somatic 602089
{Hemangioma, capillary infantile, susceptibility to} 602089
Associated With kdr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041348 VEGFR-2, Transmembrane domain
Family IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR-2, Transmembrane domain
UniProtKB:Q5GIT4 1357
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations