ZFIN ID: ZDB-GENE-040930-4
Gene Name: RNA polymerase I and III subunit D
Gene Symbol: polr1d    Nomenclature History

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Previous Names: im:7162148, zgc:136449 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in cartilage development; embryonic viscerocranium morphogenesis; and ribosome biogenesis. Predicted to localize to RNA polymerase I complex and RNA polymerase III complex. Is expressed in eye; lens; midbrain hindbrain boundary; optic tectum; and pharyngeal arch. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome. Orthologous to human POLR1D (RNA polymerase I and III subunit D).
Genome Resources: Alliance (1),  Gene:445412 (1),  Ensembl(GRCz11):ENSDARG00000037570 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7162148]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2393Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH polr1d HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Treacher Collins syndrome Alliance Treacher Collins syndrome 2 613717
    DISEASE ASSOCIATED WITH polr1d VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Treacher Collins syndrome polr1dhi2393Tg/hi2393Tg standard conditions Noack Watt et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA polr1d-201 (1)    Ensembl 667
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM polr1d No data available
    MARKER RELATIONSHIPS
    polr1d Contained in: [BAC] CH73-50O20 (1), CH73-119D10 (1)
    polr1d Encodes: [EST] IMAGE:7162148 (1)
    [cDNA] MGC:136449 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003888 (1)
    Genomic GenBank:CU468050 (1) 139268 nt
    Select Tool
    Polypeptide UniProtKB:Q6DRI4 (1) 112 aa
    Sequence Information (all 16)
    ORTHOLOGY for polr1d ( Chr: 14 )
    CITATIONS (28)