Gene
polr1d
- ID
- ZDB-GENE-040930-4
- Name
- RNA polymerase I and III subunit D
- Symbol
- polr1d Nomenclature History
- Previous Names
-
- im:7162148
- zgc:136449 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in cartilage development; embryonic viscerocranium morphogenesis; and ribosome biogenesis. Predicted to localize to RNA polymerase I complex and RNA polymerase III complex. Is expressed in eye; lens; midbrain hindbrain boundary; optic tectum; and pharyngeal arch. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome. Orthologous to human POLR1D (RNA polymerase I and III subunit D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162148 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Treacher Collins syndrome 2 | Alliance | Treacher Collins syndrome 2 | 613717 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Treacher Collins syndrome | polr1dhi2393Tg/hi2393Tg | standard conditions | Noack Watt et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008193 | DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site |
| Domain | IPR009025 | DNA-directed RNA polymerase, RBP11-like dimerisation domain |
| Family | IPR022905 | DNA-directed RNA polymerase subunit Rpo11-like |
| Family | IPR033898 | DNA-directed RNA polymerases I and III subunit AC19 |
| Homologous_superfamily | IPR036603 | RNA polymerase, RBP11-like subunit |
Domain Details Per Protein
| Protein | Length | DNA-directed RNA polymerase, RBP11-like dimerisation domain | DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site | DNA-directed RNA polymerases I and III subunit AC19 | DNA-directed RNA polymerase subunit Rpo11-like | RNA polymerase, RBP11-like subunit |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRI4
|
112 | |||||
|
UniProtKB:A0A8M2B3H3
|
81 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr1d-201
(1)
|
Ensembl | 667 nt |
Interactions and Pathways
No data available
Plasmids
No data available