ZFIN ID: ZDB-GENE-040927-20
Gene Name: protein phosphatase 2, regulatory subunit A, beta b
Gene Symbol: ppp2r1bb    Nomenclature History

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Previous Names: ppp2r1b, ik:tdsubc_2h3, tdsubc_2h3, wu:fa11a11, wu:fb38a08, xx:tdsubc_2h3, zgc:92493

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to contribute to protein serine/threonine phosphatase activity. Predicted to localize to cytoplasm and protein phosphatase type 2A complex. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to several human genes including PPP2R1B (protein phosphatase 2 scaffold subunit Abeta).
Genome Resources: Alliance (1),  Gene:449548 (1),  Ensembl(GRCz11):ENSDARG00000032430 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92493]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019222Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13079 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22634 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35873 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39041 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ppp2r1bb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ppp2r1bb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lung cancer Alliance Lung cancer, somatic 211980
    DISEASE ASSOCIATED WITH ppp2r1bb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function protein phosphatase regulator activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ppp2r1bb-201 (1)    Ensembl 2927
    ncRNA ppp2r1b-002 (1)    Ensembl 397
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppp2r1bb No data available
    MARKER RELATIONSHIPS
    ppp2r1bb Contained in: [BAC] DKEY-40G16 (1) (order this)
    ppp2r1bb Encodes: [EST] fa11a11 (1), fb38a08 (1), tdsubc_2h3 (1)
    [cDNA] MGC:92493 (1), MGC:114054 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001005590 (1) 2886 nt
    Genomic GenBank:BX572648 (1) 180747 nt
    Select Tool
    Polypeptide UniProtKB:Q4V911 (1) 589 aa
    Sequence Information (all 17)
    ORTHOLOGY for ppp2r1bb ( Chr: 15 )
    CITATIONS (25)