ZFIN ID: ZDB-GENE-040927-14
Gene Name: transthyretin (prealbumin, amyloidosis type I)
Gene Symbol: ttr    Nomenclature History

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Previous Name: zgc:103583

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have hormone activity and thyroid hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to localize to extracellular region. Is expressed in liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin).
Genome Resources: Alliance (1),  Gene:449556 (1),  Ensembl(GRCz11):ENSDARG00000037191 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 4 publications
Directly Submitted Expression Data: 7 figures (2 images) from Thisse et al., 2004 [MGC:103583]
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ttr
1
CRISPR2-ttr
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ttr HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
carpal tunnel syndrome Alliance Carpal tunnel syndrome, familial 115430
dystransthyretinemic hyperthyroxinemia Alliance [Dystransthyretinemic hyperthyroxinemia] 145680
transthyretin amyloidosis Alliance Amyloidosis, hereditary, transthyretin-related 105210
DISEASE ASSOCIATED WITH ttr VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process retinol metabolic process (more)
Cellular Component extracellular region (more)
Molecular Function hormone activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ttr-201 (1)    Ensembl 791
ttr-202 (1)    Ensembl 820
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ttr No data available
MARKER RELATIONSHIPS
ttr Contained in: [Fosmid] CH1073-351M12 (1)
ttr Encodes: [cDNA] MGC:103583 (1), MGC:192069 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005598 (1)
Genomic GenBank:CU468963 (1) 41920 nt
Select Tool
Polypeptide UniProtKB:B8JLL8 (1) 149 aa
Sequence Information (all 16)
ORTHOLOGY for ttr ( Chr: 20 )
CITATIONS (93)