ZFIN ID: ZDB-GENE-040917-2
Gene Name: ADAM metallopeptidase domain 10a
Gene Symbol: adam10a    Nomenclature History

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Previous Names: adam10, wu:fc03d12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).
Genome Resources: Alliance (1),  Gene:566044 (1),  Ensembl(GRCz11):ENSDARG00000053468 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH adam10a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alzheimer's disease 18 Alliance {Alzheimer disease 18, susceptibility to} 615590
reticulate acropigmentation of Kitamura Alliance Reticulate acropigmentation of Kitamura 615537
DISEASE ASSOCIATED WITH adam10a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process membrane protein ectodomain proteolysis (more)
Cellular Component integral component of membrane (more)
Molecular Function metalloendopeptidase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR034025 ADAM10/ADAM17 catalytic domain
Family IPR027053 Disintegrin and metalloproteinase domain-containing protein 10
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA adam10a-201 (1)    Ensembl 4465
adam10a-203 (1)    Ensembl 4478
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM adam10a No data available
MARKER RELATIONSHIPS
adam10a Contained in: [BAC] CH211-162M14 (1), DKEY-261O24 (1) (order this)
adam10a Encodes: [EST] fc03d12
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001159314 (1) 4450 nt
Genomic GenBank:AL935053 (1) 138341 nt
Select Tool
Polypeptide UniProtKB:A0A1D5NT24 (1) 763 aa
Sequence Information (all 22)
ORTHOLOGY for adam10a ( Chr: 7 )
CITATIONS (25)