Gene
adam10a
- ID
- ZDB-GENE-040917-2
- Name
- ADAM metallopeptidase domain 10a
- Symbol
- adam10a Nomenclature History
- Previous Names
-
- adam10
- wu:fc03d12
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to localize to synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
Domain | IPR001762 | Disintegrin domain |
Domain | IPR034025 | ADAM10/ADAM17 catalytic domain |
Domain | IPR049038 | ADAM10, cysteine-rich domain |
Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Homologous_superfamily | IPR036436 | Disintegrin domain superfamily |
Domain Details Per Protein
Protein | Length | ADAM10/ADAM17 catalytic domain | ADAM10, cysteine-rich domain | Disintegrin domain | Disintegrin domain superfamily | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IVX1
|
751 | ||||||
UniProtKB:F1RA88
|
762 | ||||||
UniProtKB:A0A1D5NT24
|
763 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
adam10a-201
(1)
|
Havana | 4465 nt | |
mRNA |
adam10a-202
(1)
|
Ensembl | 4450 nt | |
mRNA |
adam10a-203
(1)
|
Havana | 4478 nt | |
mRNA |
adam10a-204
(1)
|
Ensembl | 7623 nt |
Interactions and Pathways
No data available
Plasmids
No data available