Gene

adam10a

ID
ZDB-GENE-040917-2
Name
ADAM metallopeptidase domain 10a
Symbol
adam10a Nomenclature History
Previous Names
  • adam10
  • wu:fc03d12
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adam10a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alzheimer's disease 18 Alliance {Alzheimer disease 18, susceptibility to} 615590
reticulate acropigmentation of Kitamura Alliance Reticulate acropigmentation of Kitamura 615537
Associated With adam10a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR034025 ADAM10/ADAM17 catalytic domain
Family IPR027053 Disintegrin and metalloproteinase domain-containing protein 10
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
Domain Details Per Protein
Protein Length ADAM10/ADAM17 catalytic domain Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin domain Disintegrin domain superfamily Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide
UniProtKB:A0A0R4IVX1 751
UniProtKB:A8E4S1 560
UniProtKB:Q5XJM5 451
UniProtKB:A0A1D5NT24 763
UniProtKB:F1RA88 762
UniProtKB:A0A1D5NSQ9 757
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations