ZFIN ID: ZDB-GENE-040915-1
Gene Name: CCR4-NOT transcription complex, subunit 1
Gene Symbol: cnot1    Nomenclature History

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Previous Names: cdc39-like (1), im:7141761, kiaa1007l (1), wu:fc58h04, zgc:152902

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have estrogen receptor binding activity; molecular adaptor activity; and retinoic acid receptor binding activity. Involved in developmental growth. Predicted to localize to CCR4-NOT core complex and P-body. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1).
Genome Resources: Alliance (1),  Gene:448949 (1),  Ensembl(GRCz11):ENSDARG00000004174 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141761]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi4201bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14563 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15191 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44264 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cnot1 N/A 1
    DISEASE ASSOCIATED WITH cnot1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Holoprosencephaly 12, with or without pancreatic agenesis 618500
    DISEASE ASSOCIATED WITH cnot1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental growth (more)
    Cellular Component CCR4-NOT complex (more)
    Molecular Function estrogen receptor binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cnot1-201 (1)    Ensembl 8236
    cnot1-202 (1)    Ensembl 879
    ncRNA cnot1-003 (1)    Ensembl 791
    cnot1-004 (1)    Ensembl 847
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cnot1 No data available
    MARKER RELATIONSHIPS
    cnot1 Contained in: [BAC] DKEY-217G8 (1) (order this)
    cnot1 Encodes: [EST] fc58h04 (1), IMAGE:7141761 (1)
    [cDNA] MGC:152902 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001079951 (1)
    Genomic GenBank:CU468035 (1) 225398 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A1A5H6 (1) 2374 aa
    Sequence Information (all 20)
    ORTHOLOGY for cnot1 ( Chr: 25 )
    CITATIONS (33)