Gene

lyn

ID
ZDB-GENE-040912-7
Name
LYN proto-oncogene, Src family tyrosine kinase
Symbol
lyn Nomenclature History
Previous Names
  • zgc:92124
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in neutrophil chemotaxis; regulation of neutrophil chemotaxis; and response to wounding. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Is expressed in neuromast; post-vent region; and pronephric duct. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yoo et al., 2011
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Yoo et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lyn Human Ortholog
No data available
Associated With lyn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001452 SH3 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR035748 Tyrosine-protein kinase Lyn, SH3 domain
Domain IPR035852 Tyrosine-protein kinase Lyn, SH2 domain
Family IPR019012 RNA cap guanine-N2 methyltransferase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RNA cap guanine-N2 methyltransferase S-adenosyl-L-methionine-dependent methyltransferase Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase Lyn, SH2 domain Tyrosine-protein kinase Lyn, SH3 domain
UniProtKB:Q66I04 510
UniProtKB:F1R4S6 181
UniProtKB:A0A286YB74 800
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations