ZFIN ID: ZDB-GENE-040912-62
Gene Name: adaptor related protein complex 1 subunit sigma 3b
Gene Symbol: ap1s3b    Nomenclature History

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Previous Name: zgc:101676

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to be involved in vesicle-mediated transport. Predicted to localize to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in psoriasis 15. Is expressed in cardiovascular system; olfactory placode; and peripheral olfactory organ. Orthologous to human AP1S3 (adaptor related protein complex 1 subunit sigma 3).
Genome Resources: Alliance (1),  Gene:447897 (1),  Ensembl(GRCz11):ENSDARG00000027966 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [IMAGE:7152535]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19873 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ap1s3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    psoriasis 15 Alliance {Psoriasis 15, pustular, susceptibility to} 616106
    DISEASE ASSOCIATED WITH ap1s3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular protein transport (more)
    Cellular Component membrane (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000804 Clathrin adaptor complex, small chain
    Homologous_superfamily IPR011012 Longin-like domain superfamily
    Family IPR016635 Adaptor protein complex, sigma subunit
    Domain IPR022775 AP complex, mu/sigma subunit
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ap1s3b-201 (1)    Ensembl 1079
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ap1s3b No data available
    MARKER RELATIONSHIPS
    ap1s3b Contained in: [BAC] CH211-165B10 (1)
    ap1s3b Encodes: [EST] IMAGE:7152535 (1)
    [cDNA] MGC:101676 (1), MGC:173791 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001004635 (1) 1092 bp
    Genomic GenBank:CU467824 (1) 66918 bp
    Select Tool
    Polypeptide UniProtKB:Q66IE3 (1) 154 aa
    Sequence Information (all 14)
    ORTHOLOGY for ap1s3b ( Chr: 2 )
    CITATIONS (22)