ZFIN ID: ZDB-GENE-040912-60
Gene Name: glutathione peroxidase 1b
Gene Symbol: gpx1b    Nomenclature History

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Previous Names: wu:fd42f12, wu:fj22d06, zgc:101700

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have glutathione peroxidase activity. Predicted to be involved in several processes, including glutathione metabolic process; hydrogen peroxide catabolic process; and response to selenium ion. Predicted to localize to cytosol and mitochondrion. Is expressed in digestive system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and pseudoxanthoma elasticum. Orthologous to human GPX1 (glutathione peroxidase 1).
Genome Resources: Alliance (1),  Gene:447895 (1),  Ensembl(GRCz11):ENSDARG00000006207 (2)
GENE EXPRESSION
All Expression Data: 14 figures from 8 publications
Directly Submitted Expression Data: 7 figures (13 images) from Thisse et al., 2004 [MGC:101700]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18337 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gpx1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hemolytic anemia due to glutathione peroxidase deficiency 614164
    DISEASE ASSOCIATED WITH gpx1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component cytosol (more)
    Molecular Function glutathione peroxidase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gpx1b-201 (1)    Ensembl 866
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gpx1b No data available
    MARKER RELATIONSHIPS
    gpx1b Contained in: [BAC] DKEY-178O3 (1) (order this)
    gpx1b Encodes: [EST] fd42f12 (1), fj22d06 (1)
    [cDNA] MGC:101700 (1), MGC:191621 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004634 (1) 892 nt
    Genomic GenBank:BX957236 (1) 211391 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q66IE1 (1) 142 aa
    Sequence Information (all 21)
    ORTHOLOGY for gpx1b ( Chr: 6 )
    CITATIONS (45)