ZFIN ID: ZDB-GENE-040912-168
Gene Name: electron transfer flavoprotein dehydrogenase
Gene Symbol: etfdh    Nomenclature History

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Previous Names: fa05a11, fb71g06, wu:fa05a11, wu:fb71g06, xav (1), xavier (1), zgc:92093

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and oxidoreductase activity, oxidizing metal ions with flavin as acceptor. Involved in respiratory electron transport chain. Predicted to localize to integral component of mitochondrial inner membrane. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase).
Genome Resources: Alliance (1),  Gene:447859 (1),  Ensembl(GRCz11):ENSDARG00000038834 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p6di Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-etfdh N/A 1
    DISEASE ASSOCIATED WITH etfdh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multiple acyl-CoA dehydrogenase deficiency Alliance Glutaric acidemia IIC 231680
    DISEASE ASSOCIATED WITH etfdh VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    multiple acyl-CoA dehydrogenase deficiency etfdhp6di/p6di standard conditions Song et al., 2009
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process respiratory electron transport chain (more)
    Cellular Component integral component of membrane (more)
    Molecular Function electron-transferring-flavoprotein dehydrogenase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA etfdh-201 (1)    Ensembl 2444
    ncRNA etfdh-002 (1)    Ensembl 520
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM etfdh No data available
    MARKER RELATIONSHIPS
    etfdh Contained in: [BAC] CH211-278P11 (1)
    etfdh Contains: [SNP] rs3728666 (1)
    etfdh Encodes: [EST] fa05a11, fb71g06
    [cDNA] MGC:92093 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004598 (1) 2422 nt
    Genomic GenBank:CR812918 (1) 147571 nt
    Select Tool
    Polypeptide UniProtKB:Q66I16 (1) 617 aa
    Sequence Information (all 14)
    ORTHOLOGY for etfdh ( Chr: 14 )
    CITATIONS (26)