ZFIN ID: ZDB-GENE-040912-137
Gene Name: CoA synthase
Gene Symbol: coasy    Nomenclature History

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Previous Name: zgc:92337

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Is expressed in liver; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Orthologous to human COASY (Coenzyme A synthase).
Genome Resources: Alliance (1),  Gene:447838 (1),  Ensembl(GRCz11):ENSDARG00000042747 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-coasy N/A 1
MO2-coasy N/A 1
MO3-coasy N/A 1
DISEASE ASSOCIATED WITH coasy HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neurodegeneration with brain iron accumulation 6 Alliance Neurodegeneration with brain iron accumulation 6 615643
Pontocerebellar hypoplasia, type 12 618266
DISEASE ASSOCIATED WITH coasy VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process biosynthetic process (more)
Molecular Function ATP binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA coasy-201 (1)    Ensembl 2349
ncRNA coasy-002 (1) 576
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM coasy No data available
MARKER RELATIONSHIPS
coasy Contained in: [BAC] CH211-40K21 (1)
coasy Encodes: [cDNA] MGC:92337 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001004577 (1) 2368 nt
Genomic GenBank:FP089511 (1) 158292 nt
Select Tool
Polypeptide UniProtKB:Q66HW0 (1) 554 aa
Sequence Information (all 8)
ORTHOLOGY for coasy ( Chr: 24 )
CITATIONS (20)