Gene

coasy

ID
ZDB-GENE-040912-137
Name
CoA synthase
Symbol
coasy Nomenclature History
Previous Names
  • zgc:92337
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to act upstream of or within biosynthetic process. Is expressed in liver; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Khatri et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from Khatri et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With coasy Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neurodegeneration with brain iron accumulation 6 Alliance Neurodegeneration with brain iron accumulation 6 615643
pontocerebellar hypoplasia type 12 Alliance Pontocerebellar hypoplasia, type 12 618266
Associated With coasy Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004821 Cytidyltransferase-like domain
Family IPR001977 Dephospho-CoA kinase
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Cytidyltransferase-like domain Dephospho-CoA kinase P-loop containing nucleoside triphosphate hydrolase Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:Q66HW0 554
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations