ZFIN ID: ZDB-GENE-040912-103
Gene Name: aldehyde dehydrogenase 3 family, member A2b
Gene Symbol: aldh3a2b    Nomenclature History

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Previous Name: zgc:103715 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have 3-chloroallyl aldehyde dehydrogenase activity. Predicted to be involved in cellular aldehyde metabolic process and oxidation-reduction process. Predicted to localize to integral component of membrane. Is expressed in intestinal bulb; liver; and notochord. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1) and ALDH3A2 (aldehyde dehydrogenase 3 family member A2).
Genome Resources: Alliance (1),  Gene:447920 (1),  Ensembl(GRCz11):ENSDARG00000029381 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 7 figures (5 images) from Thisse et al., 2004 [MGC:103715]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11734 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aldh3a2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Sjogren-Larsson syndrome Alliance Sjogren-Larsson syndrome 270200
    DISEASE ASSOCIATED WITH aldh3a2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular aldehyde metabolic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh3a2b-202 (1)    Ensembl 1763
    ncRNA aldh3a2b-002 (1)    Ensembl 965
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh3a2b No data available
    MARKER RELATIONSHIPS
    aldh3a2b Contained in: [BAC] CH73-331H18 (1)
    aldh3a2b Encodes: [cDNA] MGC:103715 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004658 (1) 968 nt
    Genomic GenBank:CU463284 (1) 104874 nt
    Select Tool
    Polypeptide UniProtKB:E9QH31 (1) 490 aa
    Sequence Information (all 10)
    ORTHOLOGY for aldh3a2b ( Chr: 21 )
    CITATIONS (22)