Gene

suclg1

ID
ZDB-GENE-040912-101
Name
succinate-CoA ligase GDP/ADP-forming subunit alph
Symbol
suclg1 Nomenclature History
Previous Names
  • SUCLGa (1)
  • zgc:103729
  • zgc:92738
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With suclg1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitochondrial DNA depletion syndrome 9 Alliance Mitochondrial DNA depletion syndrome 9 (encephalomyopathic type with methylmalonic aciduria) 245400
Associated With suclg1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
Conserved_site IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site
Domain IPR003781 CoA-binding
Domain IPR005811 ATP-citrate lyase/succinyl-CoA ligase
Family IPR005810 Succinyl-CoA ligase, alpha subunit
Homologous_superfamily IPR016102 Succinyl-CoA synthetase-like
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length ATP-citrate lyase/succinyl-CoA ligase ATP-citrate lyase/succinyl-CoA ligase, active site ATP-citrate lyase/succinyl-CoA ligase, conserved site CoA-binding NAD(P)-binding domain superfamily Succinyl-CoA ligase, alpha subunit Succinyl-CoA synthetase-like
UniProtKB:Q6DGX1 324
UniProtKB:Q66I58 324
UniProtKB:B8JI00 324
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations