Gene

furina

ID
ZDB-GENE-040901-1
Name
furin (paired basic amino acid cleaving enzyme) a
Symbol
furina Nomenclature History
Previous Names
  • ace of hearts (1)
  • aoh (1)
  • si:dkey-281a24.5
  • stu
  • sturgeon
  • unm_hu119 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in several processes, including determination of left/right symmetry; embryonic heart tube left/right pattern formation; and skeletal system development. Predicted to localize to integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; liver; median fin fold; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With furina Human Ortholog
No data available
Associated With furina Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Active_site IPR023827 Peptidase S8, subtilisin, Asp-active site
Active_site IPR023828 Peptidase S8, subtilisin, Ser-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR002884 P domain
Domain IPR032815 Peptidase S8, pro-domain
Domain IPR034182 Kexin/furin catalytic domain
Family IPR015500 Peptidase S8, subtilisin-related
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR038466 Peptidase S8, pro-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like repeat Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Kexin/furin catalytic domain P domain Peptidase S8, pro-domain Peptidase S8, pro-domain superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, Asp-active site Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Peptidase S8, subtilisin, Ser-active site
UniProtKB:A0A2R8QU31 552
UniProtKB:A0A2R8QME4 431
UniProtKB:F1QQ43 806
UniProtKB:B0S6Y3 560
UniProtKB:Q1KHF9 806
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations