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ZIRC
ZFIN ID: ZDB-GENE-040901-1
Gene Name: furin (paired basic amino acid cleaving enzyme) a
Gene Symbol: furina    Nomenclature History

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Previous Names: ace of hearts (1), aoh (1), si:dkey-281a24.5, stu, sturgeon, unm_hu119 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Involved in several processes, including determination of left/right symmetry; embryonic heart tube left/right pattern formation; and skeletal system development. Predicted to localize to the integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; liver; median fin fold; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme).
Genome Resources: Alliance (1),  Gene:566557 (1),  Ensembl(GRCz11):ENSDARG00000062909 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b963 Point Mutation Unknown Missense ENU
furina_unspecified Unspecified Unknown Unknown
hu119 Point Mutation Unknown Premature Stop ENU
la016009Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9922 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31552 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40848 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • td204e Point Mutation Unknown Splice Site, Exon Loss of Exon 9 ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tg419 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-furina N/A 2
    MO2-furina N/A 1
    MO3-furina N/A 2
    MO4-furina N/A 1
    DISEASE ASSOCIATED WITH furina HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH furina VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 22)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA furina-201 (1)    Ensembl 7059
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM furina No data available
    MARKER RELATIONSHIPS
    furina Contained in: [BAC] DKEY-89E6 (1) (order this), DKEY-203E10 (1) (order this), DKEY-281A24 (1) (order this)
    furina Encodes: [cDNA] MGC:162798 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045106 (1) 3126 bp
    Genomic GenBank:CR627485 (1) 180774 bp
    Select Tool
    Polypeptide UniProtKB:F1QQ43 (1) 806 aa
    Sequence Clusters UniGene:80554 (1)
    Sequence Information (all 25)
    ORTHOLOGY for furina ( Chr: 7 )
    CITATIONS (48)