ZFIN ID: ZDB-GENE-040830-1
Gene Name: polymerase (DNA directed), beta
Gene Symbol: polb    Nomenclature History

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Previous Names: DNA polymerase beta (1), wu:fa97a05, zgc:109924

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits DNA-directed DNA polymerase activity. Predicted to be involved in base-excision repair and double-strand break repair via nonhomologous end joining. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta).
Genome Resources: Alliance (1),  Gene:554204 (1),  Ensembl(GRCz11):ENSDARG00000003749 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6898371]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3512cTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa696 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15883 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-polb N/A 1
    MO2-polb N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH polb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH polb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process base-excision repair (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA-directed DNA polymerase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA polb-201 (1)    Ensembl 1609
    polb-202 (1)    Ensembl 1010
    ncRNA polb-002 (1)    Ensembl 769
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM polb No data available
    MARKER RELATIONSHIPS
    polb Contained in: [BAC] CH211-220D9 (1)
    polb Encodes: [EST] fa97a05 (1), IMAGE:6898371 (1)
    [cDNA] MGC:109924 (2), MGC:174347 (1), MGC:191550 (1), MGC:194077 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003879 (1) 1575 nt
    Genomic GenBank:AL954172 (1) 201525 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0R194 (1) 339 aa
    Sequence Information (all 33)
    ORTHOLOGY for polb ( Chr: 8 )
    CITATIONS (42)