Gene

polb

ID
ZDB-GENE-040830-1
Name
polymerase (DNA directed), beta
Symbol
polb Nomenclature History
Previous Names
  • DNA polymerase beta (1)
  • wu:fa97a05
  • zgc:109924
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits DNA-directed DNA polymerase activity. Predicted to be involved in base-excision repair and double-strand break repair via nonhomologous end joining. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polb Human Ortholog
No data available
Associated With polb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR019843 DNA polymerase family X, binding site
Domain IPR002054 DNA-directed DNA polymerase X
Domain IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
Domain IPR010996 DNA polymerase beta-like, N-terminal domain
Domain IPR018944 DNA polymerase lambda, fingers domain
Domain IPR028207 DNA polymerase beta, palm domain
Domain IPR029398 DNA polymerase beta, thumb domain
Family IPR002008 DNA polymerase family X, beta-like
Family IPR022312 DNA polymerase family X
Homologous_superfamily IPR027421 DNA polymerase lambda lyase domain superfamily
Homologous_superfamily IPR037160 DNA polymerase, thumb domain superfamily
Homologous_superfamily IPR043519 Nucleotidyltransferase superfamily
Domain Details Per Protein
Protein Length DNA-directed DNA polymerase X DNA polymerase beta-like, N-terminal domain DNA polymerase beta, palm domain DNA polymerase beta, thumb domain DNA polymerase family X DNA polymerase family X, beta-like DNA polymerase family X, binding site DNA polymerase lambda, fingers domain DNA polymerase lambda lyase domain superfamily DNA polymerase, thumb domain superfamily Helix-hairpin-helix DNA-binding motif, class 1 Nucleotidyltransferase superfamily
UniProtKB:B0R195 291
UniProtKB:Q504E8 339
UniProtKB:B0R194 339
UniProtKB:Q6DRD3 336
UniProtKB:B3DGH3 337
UniProtKB:A8E5F4 337
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations