ZFIN is now using GRCz12tu for Genomic Data
Gene
sf3b1
- ID
- ZDB-GENE-040827-3
- Name
- splicing factor 3b, subunit 1
- Symbol
- sf3b1 Nomenclature History
- Previous Names
-
- tst
- wu:fb99f09
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within several processes, including hemopoiesis; melanocyte differentiation; and neural crest cell development. Predicted to be located in nucleus. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in brain; neural tube; and trunk. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145777 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015016 | Splicing factor 3B subunit 1 |
| Domain | IPR054573 | Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat |
| Family | IPR038737 | Splicing factor 3B subunit 1-like |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat | Splicing factor 3B subunit 1 | Splicing factor 3B subunit 1-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B2S8 | InterPro | 160 | |||||
| UniProtKB:F1QQZ1 | InterPro | 1315 | |||||
| UniProtKB:A0A8M2BF86 | InterPro | 1161 | |||||
| UniProtKB:A0A8M3AW70 | InterPro | 146 | |||||
| UniProtKB:A0A8M2BF81 | InterPro | 1272 | |||||
| UniProtKB:A0AB32U214 | InterPro | 146 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers