ZFIN ID: ZDB-GENE-040826-3
Gene Name: nodal modulator
Gene Symbol: nomo    Nomenclature History

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Previous Name: loc283820

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have carbohydrate binding activity. Involved in negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Localizes to endoplasmic reticulum membrane. Orthologous to human NOMO1 (NODAL modulator 1); NOMO2 (NODAL modulator 2); and NOMO3 (NODAL modulator 3).
Genome Resources: Alliance (1),  Gene:446115 (1),  Ensembl(GRCz11):ENSDARG00000078592 (2)
GENE EXPRESSION
All Expression Data: text only from Haffner et al., 2004
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Segmentation:20-25 somites (19.0h-22.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7035 Point Mutation Unknown Premature Stop ENU
sa10937 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15655 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26715 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26716 Point Mutation Unknown Splice Site ENU
    sa33836 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nomo HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nomo VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of signal transduction (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function carbohydrate binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nomo-201 (1)    Ensembl 4434
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nomo No data available
    MARKER RELATIONSHIPS
    nomo Contained in: [BAC] DKEY-265A11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002662315 (1) 4392 nt
    Genomic GenBank:CR762392 (1) 203490 nt Blast at MegaBLAST
    Polypeptide UniProtKB:X1WEJ6 (1) 1208 aa
    Sequence Information (all 11)
    ORTHOLOGY for nomo ( Chr: 6 )
    CITATIONS (18)