Gene

dstyk

ID
ZDB-GENE-040826-2
Name
dual serine/threonine and tyrosine protein kinase
Symbol
dstyk Nomenclature History
Previous Names
  • ripk5
  • zgc:136421
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and protein kinase activity. Involved in notochord cell vacuolation. Predicted to localize to several cellular components, including apical plasma membrane; basolateral plasma membrane; and cell junction. Is expressed in notochord. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Bagwell et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dstyk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CAKUT1 Alliance Congenital anomalies of kidney and urinary tract 1 610805
hereditary spastic paraplegia 23 Alliance Spastic paraplegia 23 270750
Associated With dstyk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q4VSN1 885
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations