ZFIN ID: ZDB-GENE-040824-3
Gene Name: replication factor C (activator 1) 4
Gene Symbol: rfc4    Nomenclature History

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Previous Name: zgc:64030

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to contribute to DNA clamp loader activity. Involved in retina development in camera-type eye. Predicted to localize to the DNA replication factor C complex and nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RFC4 (replication factor C subunit 4).
Genome Resources: Alliance (1),  Gene:406435 (1),  Ensembl(GRCz11):ENSDARG00000042458 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2877aTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35172 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH rfc4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rfc4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process retina development in camera-type eye (more)
    Cellular Component DNA replication factor C complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003593 AAA+ ATPase domain
    Domain IPR003959 ATPase, AAA-type, core
    Homologous_superfamily IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    Domain IPR013748 Replication factor C, C-terminal
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript rfc4-205 (1)    Ensembl 638
    mRNA rfc4-203 (1)    Ensembl 809
    rfc4-204 (1)    Ensembl 305
    rfc4-206 (1)    Ensembl 811
    rfc4-207 (1)    Ensembl 1622
    rfc4-208 (1)    Ensembl 441
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rfc4 No data available
    MARKER RELATIONSHIPS
    rfc4 Encodes: [cDNA] MGC:64030 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_214737 (1) 1362 bp
    Polypeptide UniProtKB:A0A0R4IAU3 (1) 358 aa
    Sequence Information (all 18)
    ORTHOLOGY for rfc4 ( Chr: 11 )
    CITATIONS (30)