ZFIN ID: ZDB-GENE-040822-37
Gene Name: adenylate kinase 1
Gene Symbol: ak1    Nomenclature History

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Previous Name: zgc:91930 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have adenylate kinase activity. Predicted to be involved in nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; and purine nucleotide metabolic process. Predicted to localize to cytosol. Is expressed in cephalic musculature; hypaxial myotome region; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1).
Genome Resources: Alliance (1),  Gene:445486 (1),  Ensembl(GRCz11):ENSDARG00000001950 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (9 images) from Thisse et al., 2004 [IMAGE:6899635]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31492 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ak1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hemolytic anemia Alliance Hemolytic anemia due to adenylate kinase deficiency 612631
    DISEASE ASSOCIATED WITH ak1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ADP biosynthetic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function adenylate kinase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ak1 No data available
    MARKER RELATIONSHIPS
    ak1 Encodes: [EST] IMAGE:6899635 (1)
    [cDNA] MGC:91930 (1), MGC:191157 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003993 (1)
    Polypeptide UniProtKB:A0A2R8RXT8 (1) 194 aa
    Sequence Information (all 22)
    ORTHOLOGY for ak1 ( Chr: 5 )
    CITATIONS (32)