ZFIN ID: ZDB-GENE-040822-26
Gene Name: calcitonin receptor-like a
Gene Symbol: calcrla    Nomenclature History

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Previous Names: CALCRL1 (1), calcrl (1), CLR1 (1), crlr-1 (1), CRLR1 (1), crlr (1), im:7141310, zgc:100872 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have adrenomedullin receptor activity and calcitonin gene-related peptide receptor activity. Involved in blood vessel morphogenesis; chloride ion homeostasis; and somitogenesis. Predicted to localize to plasma membrane. Is expressed in several structures, including cardiovascular system; neural tube; pleuroperitoneal region; trunk; and ventral mesoderm. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor).
Genome Resources: Alliance (1),  Gene:445508 (1),  Ensembl(GRCz11):ENSDARG00000011473 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34724 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41506 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41507 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-calcrla N/A 2
    MO2-calcrla N/A 1
    MO3-calcrla N/A 1
    DISEASE ASSOCIATED WITH calcrla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Lymphatic malformation 8 618773
    DISEASE ASSOCIATED WITH calcrla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process somitogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcitonin receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA calcrla-201 (1)    Ensembl 1684
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM calcrla No data available
    MARKER RELATIONSHIPS
    calcrla Contained in: [BAC] DKEY-249O24 (1) (order this)
    calcrla Encodes: [EST] IMAGE:7141310 (1)
    [cDNA] MGC:100872 (1), MGC:158571 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004010 (1) 1690 nt
    Genomic GenBank:BX470245 (1) 132054 nt
    Select Tool
    Polypeptide UniProtKB:Z4YI91 (1) 474 aa
    Sequence Information (all 15)
    ORTHOLOGY for calcrla ( Chr: 9 )
    CITATIONS (29)