Gene

sdhdb

ID
ZDB-GENE-040822-17
Name
succinate dehydrogenase complex, subunit D, integral membrane protein b
Symbol
sdhdb Nomenclature History
Previous Names
  • SDHD1 (1)
  • sdhd (1)
  • sdhda
  • zgc:100986
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to contribute to succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Is expressed in female organism. Orthologous to human SDHD (succinate dehydrogenase complex subunit D).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sdhdb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Carney-Stratakis syndrome Alliance Paraganglioma and gastric stromal sarcoma 606864
paraganglioma Alliance Paragangliomas 1, with or without deafness 168000
pheochromocytoma Alliance Pheochromocytoma 171300
Mitochondrial complex II deficiency, nuclear type 3 619167
Associated With sdhdb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007992 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
Homologous_superfamily IPR034804 Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Domain Details Per Protein
Protein Length Fumarate reductase/succinate dehydrogenase, transmembrane subunit Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
UniProtKB:Q68FN7 158
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations