ZFIN ID: ZDB-GENE-040809-1
Gene Name: ATM serine/threonine kinase
Gene Symbol: atm    Nomenclature History

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Previous Name: chunp9624

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits kinase activity. Involved in DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to nucleus. Is expressed in brain; immature eye; and post-vent region. Human ortholog(s) of this gene implicated in Parkinson's disease; ataxia telangiectasia; breast cancer; endometrial cancer; and pancreatic cancer. Orthologous to human ATM (ATM serine/threonine kinase).
Genome Resources: Alliance (1),  Gene:403064 (1),  Ensembl(GRCz11):ENSDARG00000002385 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019487Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6364 Point Mutation Unknown Premature Stop ENU
    sa14977 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15974 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17959 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22587 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24975 Point Mutation Unknown Premature Stop ENU
    sa28405 Point Mutation Unknown Premature Stop ENU
    sa35807 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35808 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42483 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42484 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42485 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42486 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atm N/A 5
    TALEN1-atm
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atm HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ataxia telangiectasia Alliance Ataxia-telangiectasia 208900
    breast cancer Alliance {Breast cancer, susceptibility to} 114480
    Lymphoma, B-cell non-Hodgkin, somatic
    Lymphoma, mantle cell, somatic
    T-cell prolymphocytic leukemia, somatic
    DISEASE ASSOCIATED WITH atm VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA damage checkpoint (more)
    Cellular Component nucleus (more)
    Molecular Function kinase activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atm-202 (1)    Ensembl 7428
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atm No data available
    MARKER RELATIONSHIPS
    atm Contained in: [Fosmid] CH1073-121F8 (1), CH1073-349P20 (1), CH1073-449D16 (1), ZFOS-598C2 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002664557 (1)
    Genomic GenBank:CU655855 (1) 36037 nt
    Select Tool
    Polypeptide UniProtKB:F1QJB6 (1) 3091 aa
    Sequence Information (all 24)
    ORTHOLOGY for atm ( Chr: 15 )
    CITATIONS (35)