Gene

atm

ID

ZDB-GENE-040809-1

Name

ATM serine/threonine kinase

Symbol

atm Nomenclature History

Previous Names

chunp9624

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Exhibits kinase activity. Involved in DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to nucleus. Is expressed in brain; immature eye; and post-vent region. Human ortholog(s) of this gene implicated in Parkinson's disease; ataxia telangiectasia; breast cancer; endometrial cancer; and pancreatic cancer. Orthologous to human ATM (ATM serine/threonine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atm Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ataxia telangiectasia	Alliance	Ataxia-telangiectasia	208900
breast cancer	Alliance	{Breast cancer, susceptibility to}	114480
		Lymphoma, B-cell non-Hodgkin, somatic
		Lymphoma, mantle cell, somatic
		T-cell prolymphocytic leukemia, somatic

Associated With atm Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR014009	PIK-related kinase
Domain	IPR021668	Telomere-length maintenance and DNA damage repair
Domain	IPR044107	ATM, catalytic domain
Family	IPR015519	Serine/threonine-protein kinase ATM/Tel1
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily