Gene

atm

ID
ZDB-GENE-040809-1
Name
ATM serine/threonine kinase
Symbol
atm Nomenclature History
Previous Names
  • chunp9624
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits kinase activity. Involved in DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; ataxia telangiectasia; breast cancer; endometrial cancer; and pancreatic cancer. Is expressed in brain; immature eye; and post-vent region. Orthologous to human ATM (ATM serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atm Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ataxia telangiectasia Alliance Ataxia-telangiectasia 208900
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Lymphoma, B-cell non-Hodgkin, somatic
Lymphoma, mantle cell, somatic
T-cell prolymphocytic leukemia, somatic
Associated With atm Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR014009 PIK-related kinase
Domain IPR021668 Telomere-length maintenance and DNA damage repair
Domain IPR044107 ATM, catalytic domain
Family IPR015519 Serine/threonine-protein kinase ATM/Tel1
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Domain Details Per Protein
Protein Length ATM, catalytic domain FATC domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Serine/threonine-protein kinase ATM/Tel1 Telomere-length maintenance and DNA damage repair
UniProtKB:Q70AK4 907
UniProtKB:Q59IS5 2773
UniProtKB:R4GE34 2330
UniProtKB:F1QJB6 3091
UniProtKB:B6V8N0 416
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations