Gene

atm

ID

ZDB-GENE-040809-1

Name

ATM serine/threonine kinase

Symbol

atm Nomenclature History

Previous Names

chunp9624

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Enables kinase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; regulation of cell cycle phase transition; and swimming behavior. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; caudal fin; immature eye; and post-vent region. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Chen et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atm Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ataxia telangiectasia	Alliance	Ataxia-telangiectasia	208900
breast cancer	Alliance	{Breast cancer, susceptibility to}	114480
		Lymphoma, B-cell non-Hodgkin, somatic
		Lymphoma, mantle cell, somatic
		T-cell prolymphocytic leukemia, somatic

Associated With atm Via Experimental Models

Human Disease	Fish	Conditions	Citations
ataxia telangiectasia	atm^{zf3863/zf3863} (TU)	standard conditions	Chen et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR014009	PIK-related kinase
Domain	IPR021668	Telomere-length maintenance and DNA damage repair
Domain	IPR044107	ATM, catalytic domain
Family	IPR038980	Serine/threonine-protein kinase ATM, plant
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily