ZFIN ID: ZDB-GENE-040808-62
Gene Name: 4-hydroxyphenylpyruvate dioxygenase b
Gene Symbol: hpdb    Nomenclature History

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Previous Names: hpd, zgc:92456

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to the Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in tyrosinemia type III. Is expressed in several structures, including ectoderm; epidermis; median fin fold; neurons; and otic vesicle. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).
Genome Resources: Alliance (1),  Gene:445287 (1),  Ensembl(GRCz11):ENSDARG00000044935 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21339 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25400 Point Mutation Unknown Splice Site ENU
    sa27241 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hpdb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hawkinsinuria Alliance Hawkinsinuria 140350
    tyrosinemia type III Alliance Tyrosinemia, type III 276710
    DISEASE ASSOCIATED WITH hpdb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process aromatic amino acid family metabolic process (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function 4-hydroxyphenylpyruvate dioxygenase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
    Family IPR005956 4-hydroxyphenylpyruvate dioxygenase
    Homologous_superfamily IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
    Domain IPR037523 Vicinal oxygen chelate (VOC) domain
    Domain IPR041735 4-hydroxyphenylpyruvate dioxygenase, C-terminal
    Domain IPR041736 4-hydroxyphenylpyruvate dioxygenase, N-terminal
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hpdb No data available
    MARKER RELATIONSHIPS
    hpdb Contained in: [BAC] DKEY-179C19 (order this)
    hpdb Encodes: [EST] IMAGE:7162729 (1)
    [cDNA] MGC:92456 (1), MGC:192968 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003742 (1) 1640 bp
    Genomic GenBank:CR786581 166217 bp
    Select Tool
    Polypeptide UniProtKB:F1Q986 (1) 393 aa
    Sequence Information (all 16)
    ORTHOLOGY for hpdb ( Chr: 8 )
    CITATIONS (17)