ZFIN is now using GRCz12tu for Genomic Data
Gene
lhcgr
- ID
- ZDB-GENE-040806-3
- Name
- luteinizing hormone/choriogonadotropin receptor
- Symbol
- lhcgr Nomenclature History
- Previous Names
-
- lhr
- GTHR-II
- zfGTHR-II
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables luteinizing hormone receptor activity. Acts upstream of or within gonad development; ovulation; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in digestive system; endocrine system; female organism; and gonad. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial male-limited precocious puberty | Alliance | Leydig cell adenoma, somatic, with precocious puberty | 176410 |
| familial male-limited precocious puberty | Alliance | Precocious puberty, male | 176410 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with hypergonadotropic hypogonadism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with pseudohermaphroditism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Luteinizing hormone resistance, female | 238320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR002131 | Glycoprotein hormone receptor family |
| Family | IPR002273 | Lutropin-choriogonadotropic hormone receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Additional Resources | Length | BspA-type LRR region | Glycoprotein hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat domain superfamily | Lutropin-choriogonadotropic hormone receptor |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TCF8 | InterPro | 708 | ||||||
| UniProtKB:A0A8M9QNC1 | InterPro | 683 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers