ZFIN ID: ZDB-GENE-040806-3
Gene Name: luteinizing hormone/choriogonadotropin receptor
Gene Symbol: lhcgr
Previous Names: lhr, GTHR-II, zfGTHR-II
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Wild-type Stages, Structures: Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth) to Adult (90d-730d, breeding adult)
  granulosa cell layer, gut, hypophysis, liver (all 12) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22377 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa35588 Point Mutation Unknown Unknown ENU
    umo4 Small Deletion Unknown Unknown TALEN
    zf593 Indel Exon 1 Premature Stop TALEN
    Targeting reagents: TALEN1-lhcgr (1), TALEN2-lhcgr (1)
    PHENOTYPE
    Data: Fig. 6 from Chu et al., 2014
    Observed in: ovarian follicle stage IV, ovary, ovulation, postovulatory follicle
    DISEASE ASSOCIATED WITH lhcgr HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Leydig cell hypoplasia with hypergonadotropic hypogonadism 238320
    Leydig cell adenoma, somatic, with precocious puberty 176410
    Leydig cell hypoplasia with pseudohermaphroditism 238320
    Luteinizing hormone resistance, female 238320
    Precocious puberty, male 176410
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process male gonad development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function luteinizing hormone receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000276 (1)
  • InterPro:IPR002131 (1)
  • InterPro:IPR002273 (1)
  • InterPro:IPR017452 (1)
  • InterPro:IPR024635 (1)
  • InterPro:IPR026906 (1)
  • InterPro:IPR032675 (1)
  • PROSITE:PS00237 (1)
  • PROSITE:PS50262 (1)
  • Pfam:PF00001 (1)
  • Pfam:PF12369 (1)
  • Pfam:PF13306 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lhcgr-001 (1) 3001
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM lhcgr No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    lhcgrContained in: [Fosmid] CH1073-164F11 (1) (order this), CH1073-174F20 (1) (order this), CH1073-268L12 (1) (order this)
    lhcgrEncodes: [cDNA] MGC:193516 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205625 (1) 2965bp
    Genomic GenBank:CU633795 (1) 36941bp
    Select Tool
    Polypeptide UniProtKB:B3DGM7 (1) 708aa
    Sequence Clusters UniGene:90854 (1)
    Sequence Information (all 19)
    OTHER lhcgr GENE PAGES
  • Gene:402920 (1)
  • VEGA:OTTDARG00000029440 (1)
  • Ensembl(GRCz10):ENSDARG00000026081 (1)
  • ORTHOLOGY for lhcgr (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human LHCGR 2
  • Gene:3973
  • OMIM:152790
  • HGNC:6585
  • Amino acid sequence comparison (3)
    Mouse Lhcgr 17
  • MGI:96783
  • Gene:16867
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (62)