Gene
lhcgr
- ID
- ZDB-GENE-040806-3
- Name
- luteinizing hormone/choriogonadotropin receptor
- Symbol
- lhcgr Nomenclature History
- Previous Names
-
- lhr
- GTHR-II
- zfGTHR-II
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits luteinizing hormone receptor activity. Involved in gamete generation and gonad development. Predicted to localize to integral component of plasma membrane. Is expressed in digestive system; female organism; gonad; and hypophysis. Human ortholog(s) of this gene implicated in Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial male-limited precocious puberty | Alliance | Leydig cell adenoma, somatic, with precocious puberty | 176410 |
| familial male-limited precocious puberty | Alliance | Precocious puberty, male | 176410 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with hypergonadotropic hypogonadism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with pseudohermaphroditism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Luteinizing hormone resistance, female | 238320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Domain | IPR024635 | Gonadotropin hormone receptor, transmembrane domain |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR002131 | Glycoprotein hormone receptor family |
| Family | IPR002273 | Lutropin-choriogonadotropic hormone receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR026906 | BspA type Leucine rich repeat region |
Domain Details Per Protein
| Protein | Length | BspA type Leucine rich repeat region | Glycoprotein hormone receptor family | Gonadotropin hormone receptor, transmembrane domain | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat domain superfamily | Lutropin-choriogonadotropic hormone receptor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5UK77
|
708 | |||||||
|
UniProtKB:Q6TCF8
|
708 | |||||||
|
UniProtKB:B3DGM7
|
708 | |||||||
|
UniProtKB:B8JME5
|
708 |
Interactions and Pathways
No data available
Plasmids
No data available