ZFIN ID: ZDB-GENE-040806-3
Gene Name: luteinizing hormone/choriogonadotropin receptor
Gene Symbol: lhcgr    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: lhr, GTHR-II, zfGTHR-II

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits luteinizing hormone receptor activity. Involved in gamete generation and gonad development. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in Leydig cell tumor; breast cancer; and gonadal disease. Is expressed in digestive system; gonad; and hypophysis. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
Genome Resources: Alliance (1),  Gene:402920 (1),  Ensembl(GRCz11):ENSDARG00000026081 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22377 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35588 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • umo4 Small Deletion Unknown Unknown TALEN
    zf593 Indel Exon 1 Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-lhcgr 1
    TALEN2-lhcgr 1
    DISEASE ASSOCIATED WITH lhcgr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial male-limited precocious puberty Alliance Leydig cell adenoma, somatic, with precocious puberty 176410
    Precocious puberty, male 176410
    Leydig cell hypoplasia with hypergonadotropic hypogonadism 238320
    Leydig cell hypoplasia with pseudohermaphroditism 238320
    Luteinizing hormone resistance, female 238320
    DISEASE ASSOCIATED WITH lhcgr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process female gonad development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function luteinizing hormone receptor activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Family IPR002131 Glycoprotein hormone receptor family
    Family IPR002273 Lutropin-choriogonadotropic hormone receptor
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    Domain IPR024635 Gonadotropin hormone receptor, transmembrane domain
    Repeat IPR026906 BspA type Leucine rich repeat region
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lhcgr-201 (1)    Ensembl 3001
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lhcgr No data available
    MARKER RELATIONSHIPS
    lhcgr Contained in: [Fosmid] CH1073-164F11 (1), CH1073-174F20 (1), CH1073-268L12 (1)
    lhcgr Encodes: [cDNA] MGC:193516 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205625 (1) 2965 bp
    Genomic GenBank:CU633795 (1) 36941 bp
    Select Tool
    Polypeptide UniProtKB:B3DGM7 (1) 708 aa
    Sequence Information (all 21)
    ORTHOLOGY for lhcgr ( Chr: 13 )
    CITATIONS (115)