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Gene

lhcgr

ID
ZDB-GENE-040806-3
Name
luteinizing hormone/choriogonadotropin receptor
Symbol
lhcgr Nomenclature History
Previous Names
  • lhr
  • GTHR-II
  • zfGTHR-II
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables luteinizing hormone receptor activity. Acts upstream of or within gamete generation and gonad development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in digestive system; female organism; gonad; and hypophysis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lhcgr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial male-limited precocious puberty Alliance Leydig cell adenoma, somatic, with precocious puberty 176410
familial male-limited precocious puberty Alliance Precocious puberty, male 176410
Leydig cell hypoplasia type I Alliance Leydig cell hypoplasia with hypergonadotropic hypogonadism 238320
Leydig cell hypoplasia type I Alliance Leydig cell hypoplasia with pseudohermaphroditism 238320
Leydig cell hypoplasia type I Alliance Luteinizing hormone resistance, female 238320
Associated With lhcgr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Domain IPR024635 Gonadotropin hormone receptor, transmembrane domain
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002131 Glycoprotein hormone receptor family
Family IPR002273 Lutropin-choriogonadotropic hormone receptor
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Glycoprotein hormone receptor family Gonadotropin hormone receptor, transmembrane domain GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Lutropin-choriogonadotropic hormone receptor
UniProtKB:Q6TCF8 708
UniProtKB:Q5UK77 708
UniProtKB:B3DGM7 708
UniProtKB:B8JME5 708
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations