Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040806-3
Gene Name: luteinizing hormone/choriogonadotropin receptor
Gene Symbol: lhcgr
Previous Names: lhr, GTHR-II, zfGTHR-II
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Wild-type Stages, Structures: Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth) to Adult (90d-730d, breeding adult)
  granulosa cell layer, gut, hypophysis, liver (all 12) expand
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa22377
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Leydig cell adenoma, somatic, with precocious puberty 176410
Leydig cell hypoplasia with hypergonadotropic hypogonadism 238320
Leydig cell hypoplasia with pseudohermaphroditism 238320
Luteinizing hormone resistance, female 238320
Precocious puberty, male 176410
GENE ONTOLOGY
Ontology GO Term
Biological Process luteinizing hormone signaling pathway (more)
Cellular Component integral component of membrane (more)
Molecular Function luteinizing hormone receptor activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000276 (1)
  • InterPro:IPR002131 (1)
  • InterPro:IPR002273 (1)
  • InterPro:IPR017452 (1)
  • InterPro:IPR024635 (1)
  • InterPro:IPR026906 (1)
  • PROSITE:PS00237 (1)
  • PROSITE:PS50262 (1)
  • Pfam:PF00001 (1)
  • Pfam:PF12369 (1)
  • Pfam:PF13306 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lhcgr-001 (1) 3001
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM lhcgr No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    lhcgr Contained in: [Fosmid] CH1073-164F11 (1) (order this), CH1073-174F20 (1) (order this), CH1073-268L12 (1) (order this)
    lhcgr Encodes: [cDNA] MGC:193516 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205625 (1) 2965 bp
    Genomic GenBank:CU633795 (1) 36941 bp
    Select Tool
    Polypeptide UniProtKB:B3DGM7 (1) 708 aa
    Sequence Clusters UniGene:90854 (1)
    Sequence Information (all 19)
    OTHER lhcgr GENE PAGES
  • Gene:402920 (1)
  • VEGA:OTTDARG00000029440 (1)
  • Ensembl(Zv9):ENSDARG00000026081 (1)
  • MAPPING INFORMATION
    Chr: 13 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA
    Zebrafish lhcgr 13  
    Human LHCGR 2 (2p21)
  • OMIM:152790
  • Gene:3973
  • Mouse Lhcgr 17 ( 58.35 cM)
  • MGI:96783
  • Gene:16867
  • CITATIONS (42)