ZFIN ID: ZDB-GENE-040805-1
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: braf    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytosol; mitochondrion; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; Noonan syndrome with multiple lentigines 3; astrocytoma (multiple); carcinoma (multiple); and cardiofaciocutaneous syndrome (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).
Genome Resources: Alliance (1),  Gene:403065 (1),  Ensembl(GRCz11):ENSDARG00000017661 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu590]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH braf HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome 1 Alliance Cardiofaciocutaneous syndrome 115150
lung cancer Alliance Adenocarcinoma of lung, somatic 211980
Noonan syndrome 7 Alliance Noonan syndrome 7 613706
Noonan syndrome with multiple lentigines 3 Alliance LEOPARD syndrome 3 613707
Colorectal cancer, somatic
Melanoma, malignant, somatic
Nonsmall cell lung cancer, somatic
DISEASE ASSOCIATED WITH braf VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA braf-201 (1)    Ensembl 2613
braf-202 (1)    Ensembl 2986
ncRNA braf-002 (1)    Ensembl 1818
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM braf No data available
MARKER RELATIONSHIPS
braf Contained in: [BAC] DKEY-222F8 (1) (order this)
braf Encodes: [EST] eu590 (1)
[cDNA] MGC:193731 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205744 (1) 2629 nt
Genomic GenBank:BX005210 (1) 207949 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q1LYG2 (1) 817 aa
Sequence Information (all 31)
ORTHOLOGY for braf ( Chr: 4 )
CITATIONS (32)