Gene

klhl15

ID

ZDB-GENE-040801-99

Name

kelch-like family member 15

Symbol

klhl15 Nomenclature History

Previous Names

wu:fa66h10
zgc:101051

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to be involved in protein ubiquitination. Predicted to localize to Cul3-RING ubiquitin ligase complex and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human KLHL15 (kelch like family member 15).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With klhl15 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 103	Alliance	Intellectual developmental disorder, X-linked 103	300982

Associated With klhl15 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR030597	Kelch-like protein 15, BTB/POZ domain
Domain	IPR047030	Kelch-like protein 15, BACK domain
Family	IPR017096	BTB-kelch protein
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Repeat	IPR006652	Kelch repeat type 1

Domain Details Per Protein

Protein	Length	BTB/Kelch-associated	BTB-kelch protein	BTB/POZ domain	Kelch-like protein 15, BACK domain	Kelch-like protein 15, BTB/POZ domain	Kelch repeat type 1	Kelch-type beta propeller	SKP1/BTB/POZ domain superfamily
UniProtKB:A0A8M3ANH9 InterPro	604
UniProtKB:A0A2R8QC44 InterPro	613
UniProtKB:F1R4M4 InterPro	654
UniProtKB:Q6DEL7 InterPro	604

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	klhl15-201 (1) Ensembl	Havana	2860 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	klhl15-002 (1) Ensembl	Havana	451 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations