ZFIN ID: ZDB-GENE-040801-95
Gene Name: AU RNA binding protein/enoyl-CoA hydratase
Gene Symbol: auh    Nomenclature History

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Previous Names: wu:fb81b10, zgc:101057

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase).
Genome Resources: Alliance (1),  Gene:445182 (1),  Ensembl(GRCz11):ENSDARG00000042975 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6908961]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011910Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11998 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-auh N/A 1
    PHENOTYPE
    Data: Fig. 7 from Pei et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH auh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    3-methylglutaconic aciduria type 1 Alliance 3-methylglutaconic aciduria, type I 250950
    DISEASE ASSOCIATED WITH auh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid beta-oxidation (more)
    Cellular Component mitochondrion (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA auh-201 (1)    Ensembl 1591
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM auh No data available
    MARKER RELATIONSHIPS
    auh Contained in: [BAC] CH211-237I9 (1)
    auh Encodes: [EST] fb81b10 (1), IMAGE:6908961 (1)
    [cDNA] MGC:101057 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003576 (1) 1615 nt
    Genomic GenBank:CR848004 (1) 91696 nt
    Select Tool
    Polypeptide UniProtKB:F1RDX1 (1) 325 aa
    Sequence Information (all 15)
    ORTHOLOGY for auh ( Chr: 10 )
    CITATIONS (26)