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ZIRC
ZFIN ID: ZDB-GENE-040801-47
Gene Name: zgc:100846
Gene Symbol: zgc:100846    Nomenclature History

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Previous Names: C9orf72 (1), c13h9orf72 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Involved in several processes, including swimming; swimming behavior; and thigmotaxis. Predicted to localize to the autophagosome and endosome. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in FTDALS1. Is expressed in several structures, including central nervous system; heart; integument; liver; and pleuroperitoneal region. Orthologous to human C9orf72 (C9orf72-SMCR8 complex subunit).
Genome Resources: Alliance (1),  Gene:402895 (1),  Ensembl(GRCz11):ENSDARG00000011837 (2)

Nomenclature Note: This gene is characterized by full length cDNAs isolated as part of the Zebrafish Gene Collection (ZGC). When more is known about the gene, the current nomenclature will be replaced with more traditional zebrafish gene nomenclature. The prefix `zgc:' indicates that this gene is represented by cDNAs generated by the ZGC project.

GENE EXPRESSION
All Expression Data: 5 figures from 2 publications
Directly Submitted Expression Data: 3 figures (2 images) from Thisse et al., 2004 [IMAGE:7139850]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa30667 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-zgc:100846
    1
    CRISPR2-zgc:100846
    1
    MO1-zgc:100846 N/A 1
    MO2-zgc:100846 N/A 1
    MO3-zgc:100846 N/A 1
    MO4-zgc:100846 N/A 1
    MO5-zgc:100846 N/A 1
    DISEASE ASSOCIATED WITH zgc:100846 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    FTDALS1 Alliance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 105550
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon development (more)
    Cellular Component autophagosome (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR027819 (1)
  • PROSITE:PS51835 (1)
  • Pfam:PF15019 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zgc:100846-201 (1)    Ensembl 2427
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zgc:100846
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:zgc:100846-2xGGGGCC-GFP) UAS GFPzgc:100846 Danio rerio 2 1
    Tg(UAS:zgc:100846-80xGGGGCC-GFP) UAS GFPzgc:100846 Danio rerio 2 1
    tg(ubb:zgc:100846_89xccccgg,hsp70l:dsred) hsp70lubb DsRedzgc:100846 Danio rerio 2 1
    MARKER RELATIONSHIPS
    zgc:100846 Contained in: [BAC] CH211-129A13 (1) (order this), DKEY-221B16 (1) (order this)
    zgc:100846 Encodes: [EST] IMAGE:7139850 (1) (order this)
    [cDNA] MGC:100846 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205603 (1) 1720 bp
    Genomic GenBank:CR555301 (1) 168518 bp
    Select Tool
    Polypeptide UniProtKB:Q6TLH8 (1) 462 aa
    Sequence Clusters UniGene:82328 (1)
    Sequence Information (all 15)
    ORTHOLOGY for zgc:100846 ( Chr: 13 )
    CITATIONS (23)