ZFIN ID: ZDB-GENE-040801-46
Gene Name: coiled-coil-helix-coiled-coil-helix domain containing 4a
Gene Symbol: chchd4a    Nomenclature History

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Previous Names: chchd4, fc10g04, si:dkey-202e22.1, wu:fc10g04, zgc:100849

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have protein disulfide oxidoreductase activity. Predicted to be involved in 'de novo' posttranslational protein folding; mitochondrion organization; and protein maturation by protein folding. Predicted to localize to mitochondrial intermembrane space. Is expressed in brain; eye; head; liver; and somite. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4).
Genome Resources: Alliance (1),  Gene:445144 (1),  Ensembl(GRCz11):ENSDARG00000033376 (1)
GENE EXPRESSION
All Expression Data: Fig. 1 from Sokol et al., 2018
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns292 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
sa35133 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-chchd4a 1
    DISEASE ASSOCIATED WITH chchd4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH chchd4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process 'de novo' posttranslational protein folding (more)
    Cellular Component mitochondrial intermembrane space (more)
    Molecular Function protein disulfide oxidoreductase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chchd4a-201 (1)    Ensembl 984
    chchd4a-202 (1)    Ensembl 872
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chchd4a No data available
    MARKER RELATIONSHIPS
    chchd4a Contained in: [BAC] DKEY-202E22 (1) (order this)
    chchd4a Encodes: [EST] fc10g04, IMAGE:6904605 (1)
    [cDNA] MGC:100849 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003538 (1) 1060 nt
    Genomic GenBank:BX005001 (1) 159375 nt
    Select Tool
    Polypeptide UniProtKB:F1QKE2 (1) 146 aa
    Sequence Information (all 15)
    ORTHOLOGY for chchd4a ( Chr: 11 )
    CITATIONS (24)