Gene

bag3

ID

ZDB-GENE-040801-40

Name

BCL2 associated athanogene 3

Symbol

bag3 Nomenclature History

Previous Names

zgc:100859

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have adenyl-nucleotide exchange factor activity; chaperone binding activity; and heat shock protein binding activity. Involved in heart contraction; locomotory behavior; and skeletal muscle tissue development. Localizes to Z disc. Is expressed in fast muscle cell; heart; muscle; and slow muscle cell. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3).

Genome Resources

Note

None

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bag3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1HH	Alliance	Cardiomyopathy, dilated, 1HH	613881
myofibrillar myopathy 6	Alliance	Myopathy, myofibrillar, 6	612954

Associated With bag3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
muscular dystrophy	WT + MO4-bag3	standard conditions	Ruparelia et al., 2014
muscular dystrophy	WT + MO3-bag3 + MO4-bag3	standard conditions	Ruparelia et al., 2014

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001202	WW domain
Domain	IPR003103	BAG domain
Family	IPR039773	Molecular chaperone regulator BAG
Homologous_superfamily	IPR036020	WW domain superfamily
Homologous_superfamily	IPR036533	BAG domain superfamily