ZFIN ID: ZDB-GENE-040801-40
Gene Name: BCL2 associated athanogene 3
Gene Symbol: bag3    Nomenclature History

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Previous Name: zgc:100859

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have chaperone binding activity. Involved in heart contraction; locomotory behavior; and skeletal muscle tissue development. Localizes to Z disc. Is expressed in fast muscle cell; heart; muscle; and slow muscle cell. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3).
Genome Resources: Alliance (1),  Gene:445139 (1),  Ensembl(GRCz11):ENSDARG00000039486 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6304 Point Mutation Unknown Premature Stop ENU
sa22301 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35490 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38940 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42208 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bag3 N/A 1
    MO2-bag3 N/A 2
    MO3-bag3 N/A 2
    MO4-bag3 N/A 2
    TALEN1-bag3
    1
    DISEASE ASSOCIATED WITH bag3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1HH Alliance Cardiomyopathy, dilated, 1HH 613881
    myofibrillar myopathy 6 Alliance Myopathy, myofibrillar, 6 612954
    DISEASE ASSOCIATED WITH bag3 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    muscular dystrophy WT + MO4-bag3 standard conditions Ruparelia et al., 2014
    WT + MO3-bag3 + MO4-bag3 standard conditions Ruparelia et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component Z disc (more)
    Molecular Function chaperone binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bag3-201 (1)    Ensembl 2239
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bag3 No data available
    MARKER RELATIONSHIPS
    bag3 Contained in: [BAC] DKEY-51A16 (order this)
    bag3 Encodes: [EST] wz12756
    [cDNA] MGC:100859 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003533 (1) 2175 nt
    Genomic GenBank:BX530079 (1) 166397 nt
    Select Tool
    Polypeptide UniProtKB:F1Q9J0 (1) 480 aa
    Sequence Information (all 11)
    ORTHOLOGY for bag3 ( Chr: 13 )
    CITATIONS (26)