Gene
bag3
- ID
- ZDB-GENE-040801-40
- Name
- BCL2 associated athanogene 3
- Symbol
- bag3 Nomenclature History
- Previous Names
-
- zgc:100859
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have adenyl-nucleotide exchange factor activity; chaperone binding activity; and heat shock protein binding activity. Involved in heart contraction; locomotory behavior; and skeletal muscle tissue development. Localizes to Z disc. Is expressed in fast muscle cell; heart; muscle; and slow muscle cell. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3).
- Genome Resources
- Note
- None
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
dilated cardiomyopathy 1HH | Alliance | Cardiomyopathy, dilated, 1HH | 613881 |
myofibrillar myopathy 6 | Alliance | Myopathy, myofibrillar, 6 | 612954 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
muscular dystrophy | WT + MO4-bag3 | standard conditions | Ruparelia et al., 2014 |
muscular dystrophy | WT + MO3-bag3 + MO4-bag3 | standard conditions | Ruparelia et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | BAG domain | BAG domain superfamily | Molecular chaperone regulator BAG | WW domain | WW domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:F1Q9J0
|
480 | |||||
UniProtKB:Q6DC38
|
459 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl