Gene

prkacab

ID
ZDB-GENE-040801-208
Name
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
Symbol
prkacab Nomenclature History
Previous Names
  • zgc:91856
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; cAMP-dependent protein kinase activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; hypertrophic cardiomyopathy; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease. Is expressed in central nervous system; pronephric duct; and retinal ganglion cell layer. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkacab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cardioacrofacial dysplasia 1 619142
Cushing syndrome, ACTH-independent adrenal, somatic 615830
Associated With prkacab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Family IPR044109 cAMP-dependent protein kinase catalytic subunit
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal cAMP-dependent protein kinase catalytic subunit Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6DBV8 351
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA prkacab-201 (1) Havana 2666 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations