Gene

usb1

ID

ZDB-GENE-040801-197

Name

U6 snRNA biogenesis 1

Symbol

usb1 Nomenclature History

Previous Names

zgc:91896 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have 3'-5'-exoribonuclease activity. Involved in neutrophil differentiation and regulation of RNA splicing. Predicted to localize to nucleus. Used to study ablepharon macrostomia syndrome and poikiloderma with neutropenia. Human ortholog(s) of this gene implicated in poikiloderma with neutropenia. Is expressed in several structures, including gonad; head; heart; liver; and pectoral fin. Orthologous to human USB1 (U6 snRNA biogenesis phosphodiesterase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:91896 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
poikiloderma with neutropenia	Alliance	Poikiloderma with neutropenia	604173

Associated With usb1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
ablepharon macrostomia syndrome	AB + MO4-usb1	control	Colombo et al., 2015
poikiloderma with neutropenia	AB + MO1-usb1	standard conditions	Patil et al., 2015
poikiloderma with neutropenia	AB + MO2-usb1	standard conditions	Patil et al., 2015
poikiloderma with neutropenia	AB + MO3-usb1	control	Colombo et al., 2015