ZFIN ID: ZDB-GENE-040801-115
Gene Name: dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Gene Symbol: dpm1    Nomenclature History

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Previous Name: zgc:101018

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have dolichyl-phosphate beta-D-mannosyltransferase activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in muscle structure development. Predicted to localize to endoplasmic reticulum membrane. Is expressed in brain; cloaca; pronephric duct; solid lens vesicle; and vertical myoseptum. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic).
Genome Resources: Alliance (1),  Gene:445202 (1),  Ensembl(GRCz11):ENSDARG00000057011 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137664]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24304 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30737 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dpm1 N/A 1
    MO2-dpm1 N/A 1
    MO3-dpm1 N/A 1
    MO4-dpm1 N/A 1
    DISEASE ASSOCIATED WITH dpm1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation Ie Alliance Congenital disorder of glycosylation, type Ie 608799
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle structure development (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function dolichyl-phosphate beta-D-mannosyltransferase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dpm1-201 (1)    Ensembl 1297
    ncRNA dpm1-002 (1)    Ensembl 797
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dpm1 No data available
    MARKER RELATIONSHIPS
    dpm1 Contained in: [BAC] CH211-104F13 (1)
    dpm1 Encodes: [EST] IMAGE:7137664 (1)
    [cDNA] MGC:101018 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003596 (1) 1045 nt
    Genomic GenBank:CR352228 (1) 175139 nt
    Select Tool
    Polypeptide UniProtKB:Q6DEJ9 (1) 250 aa
    Sequence Information (all 9)
    ORTHOLOGY for dpm1 ( Chr: 23 )
    CITATIONS (26)