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ZIRC
ZFIN ID: ZDB-GENE-040730-1
Gene Name: NIMA-related kinase 1
Gene Symbol: nek1    Nomenclature History

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Previous Names: DKEY-15J16.6 (1), si:dkey-15j16.5, si:dkey-171k19.5, wu:fc38c08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in cilium assembly and cranial skeletal system development. Predicted to localize to the cilium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1).
Genome Resources: Alliance (1),  Gene:556002 (1),  Ensembl(GRCz11):ENSDARG00000022350 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa486 Point Mutation Unknown Splice Site ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nek1 N/A 1
MO2-nek1 N/A 1
DISEASE ASSOCIATED WITH nek1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
short-rib thoracic dysplasia 6 with or without polydactyly Alliance Short-rib thoracic dysplasia 6 with or without polydactyly 263520
{Amyotrophic lateral sclerosis, susceptibility to, 24} 617892
DISEASE ASSOCIATED WITH nek1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium assembly (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nek1-201 (1)    Ensembl 4795
ncRNA nek1-002 (1)    Ensembl 292
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nek1 No data available
MARKER RELATIONSHIPS
nek1 Contained in: [BAC] CH211-87E4 (1) (order this), CH211-114C9 (1) (order this), DKEY-15J16 (1) (order this), DKEY-171K19 (1) (order this)
nek1 Encodes: [EST] fc38c08
nek1 Has Artifact: [cDNA] MGC:56141 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_009294677 (1)
Genomic GenBank:BX255904 (1) 228691 bp Blast at MegaBLAST
Polypeptide UniProtKB:Q5RII7 (1) 1292 aa
Sequence Clusters UniGene:132448 (1)
Sequence Information (all 32)
ORTHOLOGY for nek1 ( Chr: 20 )
CITATIONS (22)