Gene

bcr

ID
ZDB-GENE-040724-43
Name
BCR activator of RhoGEF and GTPase
Symbol
bcr Nomenclature History
Previous Names
  • si:dkey-83d9.7 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction; positive regulation of GTPase activity; and protein phosphorylation. Predicted to be located in axon and dendritic spine. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bcr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, acute lymphocytic, Philadelphia chromosome positive, somatic 613065
chronic myeloid leukemia Alliance Leukemia, chronic myeloid, Philadelphia chromosome positive, somatic 608232
Associated With bcr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000008 C2 domain
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR015123 Bcr-Abl oncoprotein oligomerisation
Family IPR037769 Abr/Bcr
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamily
Domain Details Per Protein
Protein Length Abr/Bcr Bcr-Abl oncoprotein oligomerisation Bcr-Abl oncoprotein oligomerisation domain superfamily C2 domain C2 domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily Guanine-nucleotide dissociation stimulator, CDC24, conserved site Pleckstrin homology domain Rho GTPase-activating protein domain Rho GTPase activation protein
UniProtKB:F1Q9E9 1341
UniProtKB:A0A2R8Q802 1370
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations