ZFIN ID: ZDB-GENE-040724-243
Gene Name: galactosylceramidase a
Gene Symbol: galca    Nomenclature History

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Previous Names: si:ch211-199l3.4 (1), zgc:92561

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Localizes to lysosome. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase).
Genome Resources: Alliance (1),  Gene:449649 (1),  Ensembl(GRCz11):ENSDARG00000037064 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2004 [MGC:92561]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:6896288]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021705Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25131 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-galca N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH galca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Krabbe disease Alliance Krabbe disease 245200
    DISEASE ASSOCIATED WITH galca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process galactosylceramide catabolic process (more)
    Cellular Component lysosome (more)
    Molecular Function galactosylceramidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA galca-201 (1)    Ensembl 2809
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM galca No data available
    MARKER RELATIONSHIPS
    galca Contained in: [BAC] CH211-199L3
    galca Encodes: [EST] IMAGE:6896288 (1)
    [cDNA] MGC:92561
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001005921 (1) 2658 nt
    Genomic GenBank:AL953887 (1) 198595 nt
    Select Tool
    Polypeptide UniProtKB:Q5SNX7 (1) 660 aa
    Sequence Information (all 11)
    ORTHOLOGY for galca ( Chr: 20 )
    CITATIONS (28)