ZFIN ID: ZDB-GENE-040724-213
Gene Name: laminin, alpha 4
Gene Symbol: lama4    Nomenclature History

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Previous Names: si:busm1-189a20.2, si:dkey-119m7.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have signaling receptor binding activity. Involved in several processes, including endothelial cell development; muscle attachment; and notochord development. Predicted to localize to basement membrane. Is expressed in several structures, including cardiovascular system; head; mesoderm; pectoral fin; and trunk musculature. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4).
Genome Resources: Alliance (1),  Gene:566796 (1),  Ensembl(GRCz11):ENSDARG00000020785 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10261 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15046 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15496 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23614 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32265 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36927 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36928 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36929 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43357 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43358 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44927 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lama4
    1
    CRISPR2-lama4
    1
    MO1-lama4 N/A 4
    MO2-lama4 N/A 1
    MO3-lama4 N/A 1
    PHENOTYPE
    Data: 5 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH lama4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1JJ Alliance Cardiomyopathy, dilated, 1JJ 615235
    DISEASE ASSOCIATED WITH lama4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel morphogenesis (more)
    Cellular Component laminin complex (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lama4-001 (1) 3370
    lama4-201 (1)    Ensembl 6221
    ottdart00000004342 (1) 446
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lama4 No data available
    MARKER RELATIONSHIPS
    lama4 Contained in: [BAC] DKEY-119M7 (order this)
    [PAC] BUSM1-189A20
    lama4 Encodes: [EST] IMAGE:7160205 (1)
    [cDNA] MGC:194796 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039065 (1) 6237 nt
    Genomic GenBank:AL954744 (1) 166911 nt
    Select Tool
    Polypeptide UniProtKB:B3DK46 (1) 1871 aa
    Sequence Information (all 18)
    ORTHOLOGY for lama4 ( Chr: 20 )
    CITATIONS (33)