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ZIRC
ZFIN ID: ZDB-GENE-040724-172
Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Symbol: enpp1    Nomenclature History

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Previous Names: dgf (1), si:ch211-142e24.2, zgc:136238

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have nucleotide diphosphatase activity and phosphodiesterase I activity. Involved in phosphate ion homeostasis and regulation of bone mineralization. Predicted to localize to the cell surface. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal failure; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Is expressed in cleithrum and opercle. Orthologous to several human genes including ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).
Genome Resources: Alliance (1),  Gene:562399 (1),  Ensembl(GRCz11):ENSDARG00000005789 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4581 Point Mutation Acceptor Splice Site of Intron 10 Premature Stop
la021393Tg Transgenic Insertion Unknown Unknown DNA
sa156 Point Mutation Unknown Premature Stop
sa6620 Point Mutation Unknown Splice Site ENU
sa11561 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12823 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16086 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17193 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23648 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36987 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43395 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-enpp1 N/A 1
    DISEASE ASSOCIATED WITH enpp1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arterial calcification of infancy Alliance Arterial calcification, generalized, of infancy, 1 208000
    autosomal recessive hypophosphatemic rickets Alliance Hypophosphatemic rickets, autosomal recessive, 2 613312
    obesity Alliance {Obesity, susceptibility to} 601665
    type 2 diabetes mellitus Alliance {Diabetes mellitus, non-insulin-dependent, susceptibility to} 125853
    Cole disease 615522
    DISEASE ASSOCIATED WITH enpp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphate ion homeostasis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA enpp1-201 (1)    Ensembl 1406
    enpp1-202 (1)    Ensembl 3389
    ncRNA enpp1-002 (1)    Ensembl 716
    enpp1-003 (1)    Ensembl 543
    enpp1-005 (1)    Ensembl 593
    enpp1-006 (1)    Ensembl 925
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM enpp1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS:enpp1-TagRFP,myl7:mTurquoise) myl7UAS enpp1mTurquoiseTagRFP Danio rerio 1 3
    TgBAC(enpp1:enpp1,CMV:YFP) enpp1 enpp1YFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    enpp1 Contained in: [BAC] CH211-142E24 (order this)
    enpp1 Encodes: [cDNA] MGC:136238 (1) (order this), MGC:174996 (1) (order this), MGC:191633 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001030168 (1) 3383 bp
    Genomic GenBank:BX293547 (1) 157145 bp
    Select Tool
    Polypeptide UniProtKB:B0JZL7 (1) 878 aa
    Sequence Clusters UniGene:78641 (1)
    Sequence Information (all 27)
    ORTHOLOGY for enpp1 ( Chr: 20 )
    CITATIONS (34)