Gene

enpp1

ID
ZDB-GENE-040724-172
Name
ectonucleotide pyrophosphatase/phosphodiesterase 1
Symbol
enpp1 Nomenclature History
Previous Names
  • dgf (1)
  • si:ch211-142e24.2
  • zgc:136238
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have nucleotide diphosphatase activity and phosphodiesterase I activity. Involved in phosphate ion homeostasis and regulation of bone mineralization. Predicted to localize to cell surface. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal failure; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Is expressed in cleithrum and opercle. Orthologous to several human genes including ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With enpp1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arterial calcification of infancy Alliance Arterial calcification, generalized, of infancy, 1 208000
autosomal recessive hypophosphatemic rickets Alliance Hypophosphatemic rickets, autosomal recessive, 2 613312
obesity Alliance {Obesity, susceptibility to} 601665
type 2 diabetes mellitus Alliance {Diabetes mellitus, non-insulin-dependent, susceptibility to} 125853
Cole disease 615522
Associated With enpp1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001212 Somatomedin B domain
Domain IPR001604 DNA/RNA non-specific endonuclease
Domain IPR020821 Extracellular Endonuclease, subunit A
Family IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Family IPR029890 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
Homologous_superfamily IPR036024 Somatomedin B-like domain superfamily
Homologous_superfamily IPR044925 His-Me finger superfamily
Homologous_superfamily IPR044929 DNA/RNA non-specific endonuclease superfamily
Domain Details Per Protein
Protein Length Alkaline-phosphatase-like, core domain superfamily DNA/RNA non-specific endonuclease DNA/RNA non-specific endonuclease superfamily Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Extracellular Endonuclease, subunit A His-Me finger superfamily Somatomedin B domain Somatomedin B-like domain superfamily Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
UniProtKB:B0JZL7 878
UniProtKB:Q1JQ65 278
UniProtKB:F6NNN9 278
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations