ZFIN ID: ZDB-GENE-040724-166
Gene Name: lysine (K)-specific demethylase 6B, b
Gene Symbol: kdm6bb    Nomenclature History

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Previous Names: kdm6b, jmjd3, jmjd3a (1), si:ch211-237l4.7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits H3K27me3 modified histone binding activity and histone demethylase activity (H3-K27 specific). Involved in several processes, including common myeloid progenitor cell proliferation; fin regeneration; and primitive erythrocyte differentiation. Predicted to localize to MLL3/4 complex and nuclear chromatin. Is expressed in brain; caudal hematopoietic tissue; heart; otic vesicle; and spinal cord. Orthologous to human KDM6B (lysine demethylase 6B).
Genome Resources: Alliance (1),  Gene:563644 (1),  Ensembl(GRCz11):ENSDARG00000056929 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1307 Small Deletion Unknown Premature Stop CRISPR
la017460Tg Transgenic Insertion Unknown Unknown DNA
sa9809 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21723 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21724 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdm6bb
    2
    CRISPR2-kdm6bb
    1
    CRISPR3-kdm6bb
    1
    CRISPR4-kdm6bb 1
    MO1-kdm6bb N/A 1
    MO2-kdm6bb N/A 1
    MO3-kdm6bb N/A 1
    MO4-kdm6bb N/A 1
    MO5-kdm6bb N/A 2
    MO6-kdm6bb N/A 1
    DISEASE ASSOCIATED WITH kdm6bb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities 618505
    DISEASE ASSOCIATED WITH kdm6bb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart development (more)
    Cellular Component nucleus (more)
    Molecular Function H3K27me3 modified histone binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm6bb-201 (1)    Ensembl 5989
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm6bb No data available
    MARKER RELATIONSHIPS
    kdm6bb Contained in: [BAC] CH211-237L4
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030178 (1) 4552 nt
    Genomic GenBank:AL807389 (1) 143672 nt
    Select Tool
    Polypeptide UniProtKB:E9QG91 (1) 1719 aa
    Sequence Information (all 12)
    ORTHOLOGY for kdm6bb ( Chr: 10 )
    CITATIONS (29)