Gene

comtb

ID
ZDB-GENE-040724-164
Name
catechol-O-methyltransferase b
Symbol
comtb Nomenclature History
Previous Names
  • si:dkey-13a21.15 (1)
  • zgc:162236
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to localize to extracellular region. Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With comtb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
panic disorder Alliance {Panic disorder, susceptibility to} 167870
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
Associated With comtb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002935 Class I-like SAM-dependent O-methyltransferase
Family IPR017128 Catechol O-methyltransferase, eukaryotic
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length Catechol O-methyltransferase, eukaryotic Class I-like SAM-dependent O-methyltransferase S-adenosyl-L-methionine-dependent methyltransferase
UniProtKB:A0A2R8S029 264
UniProtKB:A4IG53 264
UniProtKB:E9QFY6 20
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations