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ZIRC
ZFIN ID: ZDB-GENE-040724-164
Gene Name: catechol-O-methyltransferase b
Gene Symbol: comtb    Nomenclature History

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Previous Names: si:dkey-13a21.15 (1), zgc:162236

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Orthologous to human COMT (catechol-O-methyltransferase).
Genome Resources: Alliance (1),  Gene:565370 (1),  Ensembl(GRCz11):ENSDARG00000025679 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6209 Point Mutation Unknown Premature Stop ENU
sa35092 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH comtb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    panic disorder Alliance {Panic disorder, susceptibility to} 167870
    schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
    DISEASE ASSOCIATED WITH comtb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process catecholamine metabolic process (more)
    Cellular Component extracellular region (more)
    Molecular Function catechol O-methyltransferase activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA comtb-201 (1)    Ensembl 2150
    comtb-202 (1)    Ensembl 231
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM comtb No data available
    MARKER RELATIONSHIPS
    comtb Contained in: [BAC] DKEY-13A21 (order this), DKEY-183J2 (1) (order this)
    comtb Encodes: [cDNA] MGC:162236 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083843 (1) 2172 bp
    Genomic GenBank:AL844847 235174 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8S029 (1) 264 aa
    Sequence Clusters UniGene:89988 (1)
    Sequence Information (all 14)
    ORTHOLOGY for comtb ( Chr: 11 )
    CITATIONS (25)