Gene
comtb
- ID
- ZDB-GENE-040724-164
- Name
- catechol-O-methyltransferase b
- Symbol
- comtb Nomenclature History
- Previous Names
-
- si:dkey-13a21.15 (1)
- zgc:162236
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Orthologous to human COMT (catechol-O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| panic disorder | Alliance | {Panic disorder, susceptibility to} | 167870 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Catechol O-methyltransferase, eukaryotic | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
|
UniProtKB:A4IG53
|
264 |
Interactions and Pathways
No data available
Plasmids
No data available