ZFIN ID: ZDB-GENE-040724-144
Gene Name: sorting nexin 14
Gene Symbol: snx14    Nomenclature History

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Previous Name: si:ch211-241p10.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity. Involved in autophagosome maturation and cerebellar Purkinje cell layer development. Predicted to localize to late endosome and lysosome. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14).
Genome Resources: Alliance (1),  Gene:555970 (1),  Ensembl(GRCz11):ENSDARG00000006332 (2)
GENE EXPRESSION
All Expression Data: Fig. S8 from Akizu et al., 2015
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa914 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16606 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23618 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23619 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29287 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-snx14 N/A 1
    DISEASE ASSOCIATED WITH snx14 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive spinocerebellar ataxia 20 Alliance Spinocerebellar ataxia, autosomal recessive 20 616354
    DISEASE ASSOCIATED WITH snx14 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagosome maturation (more)
    Cellular Component late endosome (more)
    Molecular Function phosphatidylinositol-3,5-bisphosphate binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA snx14-201 (1)    Ensembl 793
    snx14-204 (1)    Ensembl 3234
    ncRNA snx14-002 (1)    Ensembl 539
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM snx14 No data available
    MARKER RELATIONSHIPS
    snx14 Contained in: [BAC] CH211-241P10
    snx14 Encodes: [cDNA] MGC:158354 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044793 (1) 3240 nt
    Genomic GenBank:BX537259 (1) 185460 nt
    Select Tool
    Polypeptide UniProtKB:E9QIC3 (1) 936 aa
    Sequence Information (all 19)
    ORTHOLOGY for snx14 ( Chr: 20 )
    CITATIONS (24)