Gene

snx14

ID
ZDB-GENE-040724-144
Name
sorting nexin 14
Symbol
snx14 Nomenclature History
Previous Names
  • si:ch211-241p10.3
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Involved in autophagosome maturation. Acts upstream of or within autophagy and cerebellar Purkinje cell layer development. Predicted to be located in late endosome and lysosome. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Akizu et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With snx14 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 20 Alliance Spinocerebellar ataxia, autosomal recessive 20 616354
Associated With snx14 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001683 Phox homology
Domain IPR003114 Phox-associated domain
Domain IPR013937 Sorting nexin, C-terminal
Domain IPR016137 RGS domain
Domain IPR037436 Sorting nexin-14, PX domain
Domain IPR037892 SNX14, RGS domain
Homologous_superfamily IPR036305 RGS domain superfamily
Homologous_superfamily IPR036871 PX domain superfamily
Domain Details Per Protein
Protein Length Phox-associated domain Phox homology PX domain superfamily RGS domain RGS domain superfamily SNX14, RGS domain Sorting nexin-14, PX domain Sorting nexin, C-terminal
UniProtKB:Q5PNP1 934
UniProtKB:E9QIC3 936
UniProtKB:F1QJC7 264
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations