Gene

snx14

ID

ZDB-GENE-040724-144

Name

sorting nexin 14

Symbol

snx14 Nomenclature History

Previous Names

si:ch211-241p10.3

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity. Involved in autophagosome maturation and cerebellar Purkinje cell layer development. Predicted to localize to late endosome and lysosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Is expressed in central nervous system. Orthologous to human SNX14 (sorting nexin 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Akizu et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With snx14 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 20	Alliance	Spinocerebellar ataxia, autosomal recessive 20	616354

Associated With snx14 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001683	Phox homology
Domain	IPR003114	Phox-associated domain
Domain	IPR013937	Sorting nexin, C-terminal
Domain	IPR016137	RGS domain
Domain	IPR037436	Sorting nexin-14, PX domain
Domain	IPR037892	SNX14, RGS domain
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Length	Phox-associated domain	Phox homology	PX domain superfamily	RGS domain	RGS domain superfamily	RGS, subdomain 2	SNX14, RGS domain	Sorting nexin-14, PX domain	Sorting nexin, C-terminal
UniProtKB:Q5PNP1 InterPro	934
UniProtKB:A0A8M2B751 InterPro	942
UniProtKB:E9QIC3 InterPro	936

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	snx14-201 (1) Ensembl	Havana	793 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	snx14-204 (1) Ensembl	Havana	3234 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	snx14-002 (1) Ensembl	Havana	539 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations