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Gene

trpc6a

ID
ZDB-GENE-040724-114
Name
transient receptor potential cation channel, subfamily C, member 6a
Symbol
trpc6a Nomenclature History
Previous Names
  • trpc6
  • si:rp71-1p14.9
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; gut; integument; keratinocyte; and pectoral fin. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trpc6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
focal segmental glomerulosclerosis 2 Alliance Glomerulosclerosis, focal segmental, 2 603965
Associated With trpc6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005821 Ion transport domain
Domain IPR013555 Transient receptor ion channel domain
Domain IPR020683 Ankyrin repeat-containing domain
Family IPR002153 Transient receptor potential channel, canonical
Family IPR005462 Transient receptor potential channel, canonical 6
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Ion transport domain Transient receptor ion channel domain Transient receptor potential channel, canonical Transient receptor potential channel, canonical 6
UniProtKB:F1RCY2 874
UniProtKB:B3DHM0 874
UniProtKB:Q6ZM90 855
UniProtKB:F1QUD1 855
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations