Gene

trpc6a

ID
ZDB-GENE-040724-114
Name
transient receptor potential cation channel, subfamily C, member 6a
Symbol
trpc6a Nomenclature History
Previous Names
  • trpc6
  • si:rp71-1p14.9
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Is expressed in several structures, including cardiovascular system; gut; integument; keratinocyte; and pectoral fin. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trpc6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
focal segmental glomerulosclerosis 2 Alliance Glomerulosclerosis, focal segmental, 2 603965
Associated With trpc6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005821 Ion transport domain
Domain IPR013555 Transient receptor ion channel domain
Family IPR002153 Transient receptor potential channel, canonical
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily Ion transport domain Transient receptor ion channel domain Transient receptor potential channel, canonical
UniProtKB:Q6ZM90
InterPro
855
UniProtKB:F1RCY2
InterPro
874
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA trpc6a-202 (1)
Ensembl
Havana 2706 nt
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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