ZFIN ID: ZDB-GENE-040718-69
Gene Name: negative elongation factor complex member E
Gene Symbol: nelfe    Nomenclature History

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Previous Names: rdbp, zgc:92496

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Predicted to localize to NELF complex. Orthologous to human NELFE (negative elongation factor complex member E).
Genome Resources: Alliance (1),  Gene:436648 (1),  Ensembl(GRCz11):ENSDARG00000004343 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92496]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13558 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29220 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nelfe N/A 1
    MO2-nelfe N/A 1
    DISEASE ASSOCIATED WITH nelfe HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nelfe VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of hematopoietic progenitor cell differentiation (more)
    Cellular Component NELF complex (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript nelfe-202 (1)    Ensembl 322
    mRNA nelfe-201 (1)    Ensembl 1202
    nelfe-203 (1)    Ensembl 1638
    nelfe-204 (1)    Ensembl 779
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nelfe No data available
    MARKER RELATIONSHIPS
    nelfe Contained in: [BAC] CH73-276C21 (1), CH211-222E23 (1)
    nelfe Encodes: [cDNA] MGC:92496 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002375 (1) 1309 nt
    Genomic GenBank:BX537337 217375 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QPV7 (1) 394 aa
    Sequence Information (all 22)
    ORTHOLOGY for nelfe ( Chr: 19 )
    CITATIONS (25)