ZFIN ID: ZDB-GENE-040718-61
Gene Name: cathepsin L.1
Gene Symbol: ctsl.1    Nomenclature History

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Previous Names: ctslc (1), zgc:92089

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to the extracellular space and lysosome. Is expressed in gill; intestine; kidney; and testis.
Genome Resources: Alliance (1),  Gene:436641 (1),  Ensembl(GRCz11):ENSDARG00000003902 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb321 Small Deletion Unknown Unknown CRISPR
ihb322 Indel Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ctsl.1 1
MO1-ctsl.1 N/A 1
DISEASE ASSOCIATED WITH ctsl.1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ctsl.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component extracellular space (more)
Molecular Function cysteine-type peptidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Domain IPR039417 Papain-like cysteine endopeptidase
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript ctsl.1-202 (1)    Ensembl 543
mRNA ctsl.1-201 (1)    Ensembl 1434
ncRNA ctsl.1-002 (1)    Ensembl 642
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ctsl.1 No data available
MARKER RELATIONSHIPS
ctsl.1 Contained in: [BAC] CH73-172J22 (1)
ctsl.1 Encodes: [cDNA] MGC:92089 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001002368 (1) 1289 nt
Genomic GenBank:FP015965 (1) 73800 nt
Select Tool
Polypeptide UniProtKB:Q6DHT0 (1) 334 aa
Sequence Information (all 12)
ORTHOLOGY for ctsl.1 ( Chr: 17 )
CITATIONS (28)