Gene

ica1

ID
ZDB-GENE-040718-490
Name
islet cell autoantigen 1
Symbol
ica1 Nomenclature History
Previous Names
  • zgc:92566 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have protein domain specific binding activity. Predicted to be involved in regulation of insulin secretion. Predicted to localize to Golgi membrane and secretory granule membrane. Is expressed in central nervous system; neurons; rhombomere; and ventricular zone. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ica1 Human Ortholog
No data available
Associated With ica1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006723 Islet cell autoantigen Ica1, C-terminal
Domain IPR010504 Arfaptin homology (AH) domain
Family IPR024114 Islet cell autoantigen 1/Ica1-like
Family IPR030796 Islet cell autoantigen 1
Homologous_superfamily IPR027267 AH/BAR domain superfamily
Domain Details Per Protein
Protein Length AH/BAR domain superfamily Arfaptin homology (AH) domain Islet cell autoantigen 1 Islet cell autoantigen 1/Ica1-like Islet cell autoantigen Ica1, C-terminal
UniProtKB:E7EXU4
UniProtKB:Q6DHA0 449
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations