ZFIN ID: ZDB-GENE-040718-48
Gene Name: NUS1 dehydrodolichyl diphosphate synthase subunit
Gene Symbol: nus1    Nomenclature History

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Previous Names: fc21g03, NgBR (1), wu:fc21g03 (1), zgc:92136

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Involved in sprouting angiogenesis. Predicted to localize to dehydrodolichyl diphosphate synthase complex; endoplasmic reticulum; and endoplasmic reticulum membrane. Is expressed in blastomere; brain; notochord; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit).
Genome Resources: Alliance (1),  Gene:436629 (1),  Ensembl(GRCz11):ENSDARG00000027813 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9491 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nus1 N/A 1
    MO2-nus1 N/A 1
    MO3-nus1 N/A 1
    DISEASE ASSOCIATED WITH nus1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant mental retardation 55 Alliance Mental retardation, autosomal dominant 55, with seizures 617831
    congenital disorder of glycosylation Iaa Alliance ?Congenital disorder of glycosylation, type 1aa 617082
    DISEASE ASSOCIATED WITH nus1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component dehydrodolichyl diphosphate synthase complex (more)
    Molecular Function transferase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nus1-201 (1)    Ensembl 3958
    nus1-202 (1)    Ensembl 765
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nus1 No data available
    MARKER RELATIONSHIPS
    nus1 Contained in: [BAC] CH211-102B16 (1), CH211-197O9 (1)
    nus1 Encodes: [EST] fc21g03
    [cDNA] MGC:92136 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002356 (1) 1289 nt
    Genomic GenBank:CU138502 (1) 158947 nt
    Select Tool
    Polypeptide UniProtKB:Q6DHR8 (1) 274 aa
    Sequence Information (all 13)
    ORTHOLOGY for nus1 ( Chr: 20 )
    CITATIONS (25)