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Gene

nus1

ID
ZDB-GENE-040718-48
Name
NUS1 dehydrodolichyl diphosphate synthase subunit
Symbol
nus1 Nomenclature History
Previous Names
  • fc21g03
  • NgBR (1)
  • wu:fc21g03 (1)
  • zgc:92136
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in blastomere; brain; notochord; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Zhao et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Zhao et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nus1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant mental retardation 55 Alliance Mental retardation, autosomal dominant 55, with seizures 617831
congenital disorder of glycosylation Iaa Alliance ?Congenital disorder of glycosylation, type 1aa 617082
Associated With nus1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001441 Decaprenyl diphosphate synthase-like
Family IPR038887 Dehydrodolichyl diphosphate synthase complex subunit Nus1
Homologous_superfamily IPR036424 Decaprenyl diphosphate synthase-like superfamily
Domain Details Per Protein
Protein Length Decaprenyl diphosphate synthase-like Decaprenyl diphosphate synthase-like superfamily Dehydrodolichyl diphosphate synthase complex subunit Nus1
UniProtKB:Q6DHR8 274
UniProtKB:F1R7Y1 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations