Gene

gata2b

ID

ZDB-GENE-040718-440

Name

GATA binding protein 2b

Symbol

gata2b Nomenclature History

Previous Names

zgc:91840 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in definitive hemopoiesis and hematopoietic stem cell differentiation. Predicted to localize to nuclear chromatin. Is expressed in several structures, including caudal fin; dorsal aorta; hematopoietic system; neurons; and vascular cord. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 21 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91840 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Emberger syndrome	614038
		Immunodeficiency 21	614172
		{Leukemia, acute myeloid, susceptibility to}	601626
		{Myelodysplastic syndrome, susceptibility to}	614286

Associated With gata2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Family	IPR016374	Transcription factor, GATA-2/3
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type